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In fact, we are at a crossroads, in terms of needing individualized approaches to maintain DFS, while minimizing late effects and preserving health\u2010related quality of life (HRQoL). Premature morbidity and mortality translate to a high societal cost associated with the potential number of productive life years ahead in this population who are young at diagnosis. The discordance between short\u2010term lymphoma\u2010free survival and long\u2010term health and HRQoL creates a \u201csurvivorship gap\u201d which can be characterized for individuals and for subgroups of patients. The current review delineates contributors to compromised outcomes and health status in child and adolescent (paediatric) HL and frames the survivorship gap in terms of primary and secondary prevention. Primary prevention aims to titrate therapy. Secondary prevention entails strategies to intervene against late effects. Bridging the survivorship gap will be attained with enhanced knowledge of and attention to biology of the tumour and microenvironment, host genetic factors, HRQoL and sub\u2010populations with disparate outcomes.<\/jats:p>","DOI":"10.1111\/bjh.16197","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:02:30Z","timestamp":1569906150000},"page":"573-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Closing the survivorship gap in children and adolescents with Hodgkin lymphoma"],"prefix":"10.1111","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-2002","authenticated-orcid":false,"given":"Sharon M.","family":"Castellino","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division Hematology\u2010Oncology Emory School of Medicine The Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta GA 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