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A number of new therapies have been approved by the US Food and Drug Administration in the past 5\u00a0years, including blinatumomab in 2014, inotuzumab ozagamicin in 2017 and tisagenlecleucel in 2017 for relapsed\/refractory ALL. This has led to tremendous improvement in long\u2010term survival, of more than 50% in patients with precursor B\u2010ALL [50\u201370% in patients with Philadelphia chromosome (Ph)\u2010positive ALL)], 50\u201360% in T\u2010ALL and 80% in mature B\u2010ALL. Research is ongoing to optimize the benefit of targeted therapeutics with the goal of decreasing the use of cytotoxic therapies.<\/jats:p>","DOI":"10.1111\/bjh.16207","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:49:12Z","timestamp":1569905352000},"page":"207-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Targeted therapy paves the way for the cure of acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-4183","authenticated-orcid":false,"given":"Hind","family":"Rafei","sequence":"first","affiliation":[{"name":"Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop M.","family":"Kantarjian","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD 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