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Sera from some LGL leukaemia patients react to a portion of the human T\u2010cell leukaemia virus (HTLV\u20101\/2) transmembrane envelope protein, BA21, although HTLV\u20101\/2 infection is rare in LGL leukaemia patients. Here we show that family members, including spouses, of an LGL leukaemia patient had elevated LGL counts, BA21 reactivity and, additionally, recognition of HIV\u20101 gp41. Thus, both LGL leukaemia patients and clinically normal contacts sharing the same environment have evidence of exposure to a retrovirus.<\/jats:p>","DOI":"10.1111\/bjh.16223","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T07:41:13Z","timestamp":1571038873000},"page":"522-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retroviral sero\u2010reactivity in LGL leukaemia patients and family members"],"prefix":"10.1111","volume":"188","author":[{"given":"Susan B.","family":"Nyland","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine UVA Cancer Center University of Virginia Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-1691","authenticated-orcid":false,"given":"David J.","family":"Feith","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine UVA Cancer Center University of Virginia Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4147-2410","authenticated-orcid":false,"given":"Mary","family":"Poss","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine UVA Cancer Center University of Virginia Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine UVA Cancer Center University of Virginia Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Krissinger","sequence":"additional","affiliation":[{"name":"Department of Medicine Penn State College of Medicine Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard 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