{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:38:29Z","timestamp":1789015109640,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621001"],"award-info":[{"award-number":["81621001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We explored the prognostic factors for children with very high\u2010risk (VHR) Philadelphia chromosome (Ph) negative B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL) and compared the therapeutic effects of intensive chemotherapy and unmanipulated haploidentical haematopoietic stem cell transplantation (haplo\u2010HSCT) as post\u2010remission treatment in these patients undergoing first complete remission (CR1). A total of 104 paediatric patients with VHR B\u2010ALL in CR1 were retrospectively enrolled in this study, including 42 receiving unmanipulated haplo\u2010HSCT (Group A) and 62 receiving ongoing chemotherapy (Group B). Estimated 3\u2010year overall survival (OS), disease\u2010free survival (DFS) and cumulative incidence of relapse (CIR) at 36\u00b72\u00a0months median follow\u2010up were 69\u00b75\u00a0\u00b1\u00a04\u00b77%, 63\u00b75\u00a0\u00b1\u00a04\u00b78% and 32\u00b74\u00a0\u00b1\u00a04\u00b77%, respectively. Maintenance of persistent positive or conversion from negative to positive of measurable residual disease (MRD) and chemotherapy were independent risk factors associated with inferior long\u2010term survival and higher CIR. OS, DFS, and CIR differed significantly between the groups in patients with persistent positive or negative\u2010to\u2010positive MRD. Haplo\u2010HSCT may be an option for children with VHR Ph\u2010negative B\u2010ALL in CR1, especially for patients with persistent positive or negative\u2010to\u2010positive MRD, and could achieve better survival than intensive chemotherapy as post\u2010remission treatment.<\/jats:p>","DOI":"10.1111\/bjh.16226","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T14:21:34Z","timestamp":1573741294000},"page":"757-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Superior survival of unmanipulated haploidentical haematopoietic stem cell transplantation compared with intensive chemotherapy as post\u2010remission treatment for children with very high\u2010risk philadelphia chromosome negative B\u2010cell acute lymphoblastic leukaemia in first complete remission"],"prefix":"10.1111","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-8367","authenticated-orcid":false,"given":"Yu\u2010juan","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Paediatrics Peking University People\u2019s Hospital Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Haematology National Clinical Research Centre for Haematological Disease Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Haematology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-6643","authenticated-orcid":false,"given":"Xiao\u2010jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Haematology National Clinical Research Centre for Haematological 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