{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:12:15Z","timestamp":1779894735663,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>When treating limited stage classical Hodgkin lymphoma (cHL), balancing treatment efficacy and toxicity is important. Toxicities after extended\u2010field radiotherapy are well documented. Investigators have aimed at reducing toxicity without compromising efficacy, mainly by using combined modality treatment (CMT), i.e. chemotherapy and limited\u2010field radiotherapy. In some clinical trials, radiotherapy has been omitted. We evaluated 364 patients with stage I\u2010IIA cHL treated between 1999 and 2005. Patients were treated with two or four cycles of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) according to presence of risk factors, followed by 30\u00a0Gy limited\u2010field (reduced compared to involved\u2010field) radiotherapy. After a median follow\u2010up of 16\u00a0years for survival, freedom from progression at five and ten years was 93% and overall survival at 5 and 10\u00a0years was 98% and 96%, respectively. Only two relapses, out of 27, occurred after more than 5\u00a0years. There was no excess mortality compared to the general population. Of the analysed subgroups, only patients with progression within five years showed significant excess mortality. The absence of excess mortality questions the concept of omitting radiotherapy after short\u2010term chemotherapy, a strategy that has been associated with an elevated risk of relapse but not yet with a proven reduced long\u2010term excess mortality.<\/jats:p>","DOI":"10.1111\/bjh.16232","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T01:43:56Z","timestamp":1571103836000},"page":"685-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["No excess long\u2010term mortality in stage I\u2010IIA Hodgkin lymphoma patients treated with ABVD and limited field radiotherapy"],"prefix":"10.1111","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-014X","authenticated-orcid":false,"given":"Ingemar","family":"Lagerl\u00f6f","sequence":"first","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University 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