{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:24Z","timestamp":1792174764683,"version":"4.4.0"},"reference-count":107,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Neonatal Trust"},{"name":"NZ Blood Service"},{"name":"Otago Masonic Charitable Trust"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Pre\u2010term infants have one of the highest transfusion requirements within the hospital\u2010setting. The vast majority of blood transfusions performed in Neonatal Intensive Care Units (NICUs) are for medically stable pre\u2010term infants with anaemia of prematurity, with the aim of improving oxygen delivery to the vital organs during the crucial phase of growth and development. However, despite the frequency of transfusion in this population, the potential benefits and harms of \u2018top up\u2019 transfusion are not fully understood, leading to practice variation between clinicians, institutions and countries. Significant advances have been made in the prevention of anaemia of prematurity, with recent emphasis on optimising infants\u2019 circulatory volume at birth via placental transfusion and preserving infants\u2019 own blood volume through innovative minimal sampling techniques. More research is urgently needed to establish optimal transfusion thresholds for these high\u2010risk pre\u2010term infants, for whom benefits as well as adverse outcomes may have consequences that extend for decades throughout the recipients\u2019 life\u2010course. In this review, we will discuss some of the consensus and controversies regarding optimal management of anaemia in pre\u2010term infants and highlight potential areas for future research.<\/jats:p>","DOI":"10.1111\/bjh.16233","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:38:09Z","timestamp":1570408689000},"page":"354-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Management of anaemia in pre\u2010term infants"],"prefix":"10.1111","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5406-5297","authenticated-orcid":false,"given":"Maria","family":"Saito\u2010Benz","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Wellington Regional Hospital Wellington New Zealand"},{"name":"Department of Paediatrics and Child Health University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Flanagan","sequence":"additional","affiliation":[{"name":"New Zealand Blood Service Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-6790","authenticated-orcid":false,"given":"Mary J.","family":"Berry","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Wellington Regional Hospital Wellington New Zealand"},{"name":"Department of Paediatrics and Child Health University of Otago Wellington New Zealand"},{"name":"Centre for Translational Physiology University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"Cd004868","article-title":"Late erythropoiesis\u2010stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants","volume":"2","author":"Aher S.M.","year":"2019","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.02.009"},{"key":"e_1_2_9_4_1","volume-title":"Committee Opinion Number 694: Delayed Umbilical Cord Clamping After Birth","author":"American College of Obstetricians and Gynecologists","year":"2017"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40746-015-0021-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1117"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.004"},{"key":"e_1_2_9_8_1","volume-title":"Guidelines for Transfusion and Immunohaematology Laboratory Practice","author":"Australian and New Zealand Society of Blood Transfusion","year":"2016"},{"key":"e_1_2_9_9_1","unstructured":"Australian and New Zealand Council of Resuscitation (ANZCOR)2017.Guideline 13.1 \u2013 Introduction to Resuscitation of the Newborn Infant. Available at:https:\/\/resus.org.au\/guidelines\/."},{"key":"e_1_2_9_10_1","first-page":"429","article-title":"Variability in splanchnic tissue oxygenation during preterm red blood cell transfusion given for symptomatic anaemia may reveal a potential mechanism of transfusion\u2010related acute gut injury","volume":"13","author":"Bailey S.M.","year":"2015","journal-title":"Blood Transfusion"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.10.041"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01082.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1884"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368296"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12720"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80447-0"},{"key":"e_1_2_9_17_1","first-page":"831","article-title":"The role of RBC transfusion in the premature infant","volume":"138","author":"Blank J.P.","year":"1984","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-314005"},{"key":"e_1_2_9_19_1","first-page":"376","article-title":"Blood transfusion in late anemia of prematurity: effect on oxygen consumption, heart rate, and weight gain in otherwise healthy infants","volume":"21","author":"Bohler T.","year":"1994","journal-title":"Infusionstherapie und Transfusionsmedizin"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307716"},{"key":"e_1_2_9_21_1","first-page":"F396","article-title":"Physiological\u2010based cord clamping in preterm infants using a new purpose\u2010built resuscitation table: a feasibility study","volume":"104","author":"Brouwer E.","year":"2018","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal Edition"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.04.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000438452"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1586103"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12495"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01948.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301265"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.830495"},{"key":"e_1_2_9_29_1","first-page":"R158","article-title":"Multicentre study on peri\u2010 and postoperative central venous oxygen saturation in high\u2010risk surgical patients","volume":"10","author":"Collaborative Study Group on Perioperative SCVO2 Monitoring","year":"2006","journal-title":"Journal of Critical Care"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.12.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02575.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14080"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80459-7"},{"key":"e_1_2_9_34_1","volume-title":"Guide to the Preparation, Use and Quality Assurance of Blood Components","author":"European Directorate for the Quality of Medicines & HealthCare","year":"2017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.11953"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.89.4.689b"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.231"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.191023"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.04.004"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2016.09.021"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.163592"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.06.004"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-016-0032-y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335030"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(97)00010-6"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.117.015818"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1360"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1542\/peds.80.1.79","article-title":"Blood transfusion effect on the respiratory pattern of preterm infants","volume":"80","author":"Joshi A.","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00335"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.144"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1542\/peds.84.3.412","article-title":"Assessing the need for transfusion of premature infants and role of hematocrit, clinical signs, and erythropoietin level","volume":"84","author":"Keyes W.G.","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01747.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.04.007"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.05.011"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-314947"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-620872"},{"key":"e_1_2_9_57_1","first-page":"885","article-title":"Melena neonatorum with report of a case cured by transfusion","volume":"73","author":"Lambert S.","year":"1908","journal-title":"Medical Record"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(17)30197-4"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00286"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36296181918.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0274-9"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1944-5"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)70105-3"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.05.009"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2010.544647"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.06.006"},{"key":"e_1_2_9_67_1","first-page":"Cd005095","article-title":"Enteral iron supplementation in preterm and low birth weight infants","author":"Mills R.J.","year":"2012","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1997.tb03619.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.023"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2017.07.006"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2010.269"},{"key":"e_1_2_9_72_1","first-page":"CD004863","article-title":"Early erythropoietin for preventing red blood cell transfusion in preterm and\/or low birth weight infants","author":"Ohlsson A.","year":"2014","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_9_73_1","first-page":"Cd004863","article-title":"Early erythropoiesis\u2010stimulating agents in preterm or low birth weight infants","volume":"11","author":"Ohlsson A.","year":"2017","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21463"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.04.009"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1204"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.06.005"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.971746"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12518"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2017-0048"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491994"},{"key":"e_1_2_9_82_1","unstructured":"Resuscitation Council (UK) (2019)Resuscutation and support of transition of babies at birth. Available from:https:\/\/www.resus.org.uk\/resuscitation-guidelines\/resuscitation-and-support-of-transition-of-babies-at-birth\/[cited April 13]."},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14764"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14222"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14631"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2012.08.006"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12359"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309838"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101074"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.108"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.019"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138829"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303353"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0495"},{"key":"e_1_2_9_95_1","first-page":"828","article-title":"Weight gain: a response to transfusion in selected preterm infants","volume":"138","author":"Stockman J.A.","year":"1984","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.76"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2013.06.001"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2304"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.026"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21441"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199807000-00020"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.1.F22"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92994-5"},{"key":"e_1_2_9_104_1","first-page":"CD000512","article-title":"Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants","author":"Whyte R.","year":"2011","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0338"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.9-11-e520"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1680"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02677.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.16233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.16233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:30:20Z","timestamp":1694122220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.16233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,6]]},"references-count":107,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/bjh.16233"],"URL":"https:\/\/doi.org\/10.1111\/bjh.16233","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,6]]},"assertion":[{"value":"2019-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}