{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:04:45Z","timestamp":1791975885715,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mastocytosis is a rare disease with varied presentation, myriad symptomatology and variable prognosis. Most patients present with cutaneous disease and mediator\u2010related symptomatology with a small subset having systemic disease (systemic mastocytosis, SM). A subset of the latter develops synchronous or metachronous haematologic neoplasms (SM\u2010AHN), most commonly chronic myelomonocytic leukaemia (CMML). Advanced systemic mastocytosis (ASM) is seen in a relatively small number of patients and is usually associated with organ dysfunction, and may present with hepatosplenomegaly, lymphadenopathy and ascites with progression to leukaemic transformation (mast cell leukaemia\/acute myeloid leukaemia) occurring in a few patients. This paper discusses the clinical and pathologic features of the entire spectrum of SM in adults.<\/jats:p>","DOI":"10.1111\/bjh.16288","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T11:48:41Z","timestamp":1580125721000},"page":"623-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The clinical and pathological panoply of systemic mastocytosis"],"prefix":"10.1111","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-0102","authenticated-orcid":false,"given":"Deepti H.","family":"Radia","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Guys and St Thomas\u2019 NHS Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Guys and St Thomas\u2019 NHS Hospitals London 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