{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:10:51Z","timestamp":1784765451030,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The relevance of donor\u2010specific human leukocyte antigen (HLA) antibodies in HLA\u2010mismatched haematopoietic cell transplant (HCT) is known, but the importance of HLA antibodies in HLA\u2010matched HCT is unclear. We hypothesized that HLA antibodies detected before HCT would cause platelet transfusion refractoriness during HCT and investigated this in a multi\u2010centre study. Pre\u2010HCT samples from 45 paediatric patients with sickle cell disease (SCD) undergoing HLA\u2010matched HCT were tested for HLA class I antibodies. The number of platelet transfusions received before day +45 was compared between those with and without antibodies. Thirteen of 45 (29%) patients had a positive HLA class I antibody screen, and these patients received significantly more platelet transfusions than patients without antibodies (median 19 vs. 7\u00b75, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7028). This platelet transfusion association remained significant when controlling for conditioning regimen. Among alloimmunized patients, there was no association between the panel\u2010reactive antibody and the number of platelet transfusions. Patients with HLA class I antibodies also had a higher incidence of acute graft\u2010versus\u2010host disease (GVHD): 6\/13 (46%) vs. 3\/32 (9%), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011. Pre\u2010HCT HLA class I alloimmunization is associated with increased platelet transfusion support and acute GVHD in paediatric HLA\u2010matched HCT for SCD. Further studies are needed to investigate the pathobiology of this association.<\/jats:p>","DOI":"10.1111\/bjh.16298","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T10:49:03Z","timestamp":1572605343000},"page":"162-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human leukocyte antigen (HLA) class I antibodies and transfusion support in paediatric HLA\u2010matched haematopoietic cell transplant for sickle cell disease"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-7523","authenticated-orcid":false,"given":"Robert S.","family":"Nickel","sequence":"first","affiliation":[{"name":"Division of Hematology Children's National Hospital Washington DC USA"},{"name":"The George Washington University School of Medicine and Health Sciences Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Horan","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-0887","authenticated-orcid":false,"given":"Allistair","family":"Abraham","sequence":"additional","affiliation":[{"name":"Division of Hematology Children's National Hospital Washington DC USA"},{"name":"The George Washington University School of Medicine and Health Sciences Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna","family":"Qayed","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Haight","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ngwube","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Statistics The George Washington University Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L. 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