{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T21:06:47Z","timestamp":1781989607058,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Lenalidomide maintenance therapy prolonged progression\u2010free survival (PFS) <jats:italic>versus<\/jats:italic> placebo in elderly patients with diffuse large B\u2010cell lymphoma (DLBCL) responding to induction chemotherapy in the phase 3 REMARC study. This subpopulation analysis assessed the impact of lenalidomide maintenance and treatment\u2010emergent adverse events (TEAEs) on health\u2010related quality of life (HRQOL). Global health status (GHS), and physical functioning and fatigue subscales were evaluated in patients who completed the European Organisation for Research and Treatment of Cancer quality\u2010of\u2010life questionnaire\u2010C30 v3.0. The impact of TEAEs classified <jats:italic>post hoc<\/jats:italic> as subjective (patients can feel) or observable (only measurable by physicians) on dose reductions and discontinuations was assessed. Among 457 patients (lenalidomide, <jats:italic>n<\/jats:italic>\u00a0=\u00a0229; placebo, <jats:italic>n<\/jats:italic>\u00a0=\u00a0228), mean (standard deviation) GHS was similar between treatment arms [68\u00b72 (20\u00b77) <jats:italic>Versus<\/jats:italic> 72\u00b70 (17\u00b78)] at randomisation and remained similar during maintenance. Patients receiving lenalidomide experienced no meaningful changes in GHS, physical functioning, or fatigue. Observable TEAEs were more common (81\u00b71% <jats:italic>Versus<\/jats:italic> 66\u00b73%) and more likely to lead to dose reductions, than subjective TEAEs in both arms. PFS was superior in the lenalidomide arm regardless of dose reduction. Lenalidomide maintenance prolonged PFS and did not negatively impact HRQOL in patients with DLBCL despite TEAEs being more common, when compared with placebo.<\/jats:p>","DOI":"10.1111\/bjh.16300","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T18:40:26Z","timestamp":1573238426000},"page":"84-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lenalidomide maintenance for diffuse large B\u2010cell lymphoma patients responding to R\u2010CHOP: quality of life, dosing, and safety results from the randomised controlled REMARC study"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-2448","authenticated-orcid":false,"given":"Catherine","family":"Thieblemont","sequence":"first","affiliation":[{"name":"Hemato\u2010Oncology APHP H\u00f4pital Saint\u2010Louis Paris 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