{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:39:31Z","timestamp":1788305971196,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,29]],"date-time":"2019-12-29T00:00:00Z","timestamp":1577577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003483","name":"Hebrew University of Jerusalem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mucormycosis has emerged as an increasingly important cause of morbidity and mortality in immunocompromised patients, but contemporary data in children are lacking. We conducted a nationwide multicentre study to investigate the characteristics of mucormycosis in children with haematological malignancies. The cohort included 39 children with mucormycosis: 25 of 1136 children (incidence 2\u00b72%) with acute leukaemias prospectively enrolled in a centralized clinical registry in 2004\u20132017, and an additional 14 children with haematological malignancies identified by retrospective search of the databases of seven paediatric haematology centres. Ninety\u2010two percent of mucormycosis cases occurred in patients with acute leukaemias. Mucormycosis was significantly associated with high\u2010risk acute lymphoblastic leukaemia (OR 3\u00b775; 95% CI 1\u00b751\u20139\u00b737; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004) and with increasing age (OR 3\u00b758; 95% CI 1\u00b724\u20139\u00b777; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701). Fifteen patients (38%) died of mucormycosis. Rhinocerebral pattern was independently associated with improved 12\u2010week survival (OR 9\u00b743; 95% CI 1\u00b747\u201360\u00b766; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702) and relapsed underlying malignancy was associated with increased 12\u2010week mortality (OR 6\u00b742; 95% CI, 1\u00b701\u201340\u00b794; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705). In patients receiving frontline therapy for their malignancy (<jats:italic>n<\/jats:italic>\u00a0=\u00a024), one\u2010year cumulative mucormycosis\u2010related mortality was 21\u00a0\u00b1\u00a08% and five\u2010year overall survival was 70\u00a0\u00b1\u00a08%. This largest paediatric population\u2010based study of mucormycosis demonstrates that children receiving frontline therapy for their haematological malignancy are often salvageable.<\/jats:p>","DOI":"10.1111\/bjh.16329","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T05:55:03Z","timestamp":1577685303000},"page":"339-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mucormycosis in children with haematological malignancies is a salvageable disease: a report from the Israeli Study Group of Childhood Leukemia"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-7578","authenticated-orcid":false,"given":"Sarah","family":"Elitzur","sequence":"first","affiliation":[{"name":"The Rina Zaizov Division of Pediatric Hematology\u2010Oncology Schneider Children's Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv 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