{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:23:56Z","timestamp":1790051036900,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although chimeric antigen receptor T cells (CAR\u2010T) targeted at CD19 or CD22 have achieved high complete remission (CR) in refractory\/relapsed B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL), it is uncertain if allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) should be performed after CAR\u2010T therapy to accomplish a sustainable remission. Fifty\u2010two cases with relapsed\/refractory B\u2010ALL who underwent allo\u2010HSCT after CR by CD19 or CD22 CAR\u2010T were enrolled. The median time from CAR\u2010T infusion to allo\u2010HSCT was 50 (34\u201398)\u00a0days. Myeloablative reduced\u2010intensity conditioning (RIC) with total body irradiation\/fludarabine\u2010based or busulfan\/fludarabine\u2010based regimens was used. Incidences of grade II\u2013IV acute graft\u2010versus\u2010host disease (aGVHD) and severe aGVHD were 23\u00b71% and 5\u00b78% respectively. Of 48 evaluable cases, 16 developed chronic GVHD (cGVHD) and in three of them the pattern was extensive. With a median follow\u2010up of 334 (41\u2013479)\u00a0days, one\u2010year overall survival and event\u2010free survival (EFS) were 87\u00b77% and 73\u00b70%. One\u2010year relapse rate and transplant\u2010related mortality (TRM) were 24\u00b77% and 2\u00b72% respectively. With quick bridge to allo\u2010HSCT after CAR\u2010T therapy, high EFS for refractory\/relapsed B\u2010ALL has been achieved in this relatively large cohort. Our myeloablative RIC regimens have resulted in low incidences of aGVHD, cGVHD, viral reactivation and very low TRM even majority of transplants from haploidentical donors. Long\u2010term follow\u2010up is warranted.<\/jats:p>","DOI":"10.1111\/bjh.16339","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T22:53:34Z","timestamp":1577141614000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Chimeric antigen receptor T\u2010cell therapy as a bridge to haematopoietic stem cell transplantation for refractory\/relapsed B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-0119","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiren","family":"Chen","sequence":"additional","affiliation":[{"name":"The 7th Medical Center of PLA Army Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyou","family":"Tan","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"The 7th Medical Center of PLA Army Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Boren Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Alvarnas J.C. 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