{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:17:06Z","timestamp":1793150226282,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with EBV\u2010positive diffuse large B cell lymphoma not otherwise specified (EBV<jats:sup>+<\/jats:sup> DLBCL (NOS)) recurrently present with advanced age and reduced performance status. They are therefore insufficiently represented in clinical trials and treatment is likely to differ. Here we assess clinicopathological characteristics, therapeutic variability and clinical outcome in the largest consecutively diagnosed EBV<jats:sup>+<\/jats:sup> DLBCL (NOS) cohort published to date (<jats:italic>n<\/jats:italic>\u00a0=\u00a080; median age 70\u00a0years; range 19\u201390). Centralized and systematic haematopathological panel review was performed. By immunohistochemistry 60\/80 patients were CD30\u2010positive. Further, we identified nine EBV<jats:sup>+<\/jats:sup> DLBCL (NOS) patients with associated or composite peripheral T cell lymphoma at diagnosis or relapse (preceded by clonal T cell populations within the initial DLBCL biopsy in 4\/5 cases). Most patients (80%) were treated with R\u2010CHOP\u2010type therapy and 16 patients received none or less intensiveprotocols. Upon univariate analysis both R\u2010CHOP\u2010type therapy (OS: <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001; PFS: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0617) and negativity for CD30 (OS: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0002; PFS: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0002) showed a protective 66 effect, maintained upon multivariate analysis. In a propensity\u2010score matched analysis with a cohort of non\u2010EBV<jats:sup>+<\/jats:sup> DLBCL (NOS) patients, balanced for all revised\u2010international prognostic index factors, we found an EBV\u2010association to hold no significant impact on progression\u2010free and overall survival whilst exhibiting a trend favouring EBV\u2010negativity (OS: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.116; PFS: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.269). Our findings provide insight into the clinical course of EBV<jats:sup>+<\/jats:sup> DLBCL (NOS), highlight the ramifications of CD30\u2010expression and underline the superior therapeutic efficacy of R\u2010CHOP immunochemotherapy. Alternative therapies, incorporating tumour biology (e.g. CD30 directed therapies) need to be explored in EBV<jats:sup>+<\/jats:sup> DLBCL (NOS) patients. Moreover our data advert to the close relationship between EBV<jats:sup>+<\/jats:sup> DLBCL (NOS) and peripheral T cell lymphomas.<\/jats:p>","DOI":"10.1111\/bjh.16342","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:25:24Z","timestamp":1579566324000},"page":"257-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Impact of treatment variability and clinicopathological characteristics on survival in patients with Epstein\u2010Barr\u2010Virus positive diffuse large B cell lymphoma"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-7125","authenticated-orcid":false,"given":"Hanno M.","family":"Witte","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology Federal Armed Hospital Ulm Ulm Germany"},{"name":"Department of Haematology and Oncology University Hospital of Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Merz","sequence":"additional","affiliation":[{"name":"H\u00e4matopathologie L\u00fcbeck Reference Centre for Lymph Node Pathology and Haematopathology L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Biersack","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology University Hospital of Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Bernard","sequence":"additional","affiliation":[{"name":"H\u00e4matopathologie L\u00fcbeck Reference Centre for Lymph Node Pathology and Haematopathology L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Riecke","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Federal Armed Hospital Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital of Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Lehnert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital of Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"von Bubnoff","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology University Hospital of Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred C.","family":"Feller","sequence":"additional","affiliation":[{"name":"H\u00e4matopathologie L\u00fcbeck Reference Centre for Lymph Node Pathology and Haematopathology L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-4554","authenticated-orcid":false,"given":"Niklas","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology University Hospital of Schleswig\u2010Holstein L\u00fcbeck 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