{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:41Z","timestamp":1791561041344,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Endemic Burkitt lymphoma (eBL) is an aggressive childhood B\u2010cell lymphoma associated with <jats:italic>Plasmodium falciparum<\/jats:italic> (<jats:italic>Pf<\/jats:italic>) malaria and Epstein\u2013Barr virus (EBV) infections. Variation in the Human Leukocyte Antigen (HLA) system is suspected to play a role, but assessments using less accurate serology\u2010based HLA typing techniques in small studies yielded conflicting results. We studied 200 eBL cases and 400 controls aged 0\u201315\u00a0years enrolled in northern Uganda and typed by accurate high\u2010resolution HLA sequencing methods. HLA results were analyzed at one\u2010 or two\u2010field resolution. Odds ratios and 95% confidence intervals (aOR, 95% CI) for eBL risk associated with common HLA alleles <jats:italic>versus<\/jats:italic> alleles that were rare (&lt;1%)\u00a0or\u00a0differed by &lt;2% between the cases and controls as the reference category, were estimated using multiple logistic regression adjusting for age, sex, microgeography, region, malaria positivity and treatment history, and genetic variants associated with eBL. Compared to the controls, eBL cases had a lower frequency of <jats:italic>HLA\u2010A*02<\/jats:italic> (aOR\u00a0=\u00a00\u00b759, 95% CI 0\u00b738\u20130\u00b791), <jats:italic>HLA\u2010B*41<\/jats:italic> (aOR\u00a0=\u00a00\u00b736, 95% CI 0\u00b713\u20131\u00b700), and <jats:italic>HLA\u2010B*58<\/jats:italic> alleles (aOR\u00a0=\u00a00\u00b759, 95% CI 0\u00b736\u20130\u00b797). eBL cases had a lower frequency of <jats:italic>HLA\u2010DPB1<\/jats:italic> homozygosity (aOR\u00a0=\u00a00\u00b757, 95% CI 0\u00b740\u20130\u00b782) but a higher frequency of <jats:italic>HLA\u2010DQA1<\/jats:italic> homozygosity (aOR\u00a0=\u00a02\u00b719, 95% CI 1\u00b742\u20133\u00b737). Our results suggest that variation in HLA may be associated with eBL risk.<\/jats:p>","DOI":"10.1111\/bjh.16398","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T05:40:54Z","timestamp":1582090854000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Variation in the Human Leukocyte Antigen system and risk for endemic Burkitt lymphoma in northern Uganda"],"prefix":"10.1111","volume":"189","author":[{"given":"Samuel","family":"Kirimunda","sequence":"first","affiliation":[{"name":"College of Health Sciences Makerere University Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Verboom","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine Hannover 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