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However it has a devastating affects on adults, where multi\u2010agent chemotherapy is the standard of care with allogeneic stem cell transplantation for those who are eligible. New treatments are required to extend remission and prevent relapse to improve patient survival rates. We used serum profiling to compare samples from presentation adult B\u2010ALL patients with age\u2010 and sex\u2010matched healthy volunteer (HV) sera and identified 69 differentially recognised antigens (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00\u00b702). BMX, DCTPP1 and VGLL4 showed no differences in transcription between patients and healthy donors but were each found to be present at higher levels in B\u2010ALL patient samples than HVs by ICC. BMX plays a crucial role in the Bruton's Tyrosine Kinase (BTK) pathway which is bound by the BTK inhibitor, ibrutinib, suggesting adult B\u2010ALL would also be a worthy target patient group for future clinical trials. We have shown the utility of proto\u2010array analysis of B\u2010ALL patient sera, predominantly from young adults, to help characterise the B\u2010ALL immunome and identified a new target patient population for existing small molecule therapy.<\/jats:p>","DOI":"10.1111\/bjh.16407","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T06:00:26Z","timestamp":1581919226000},"page":"500-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum profiling identifies ibrutinib as a treatment option for young adults with B\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-367X","authenticated-orcid":false,"given":"Stephanie","family":"Jordaens","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Hull Hull UK"},{"name":"Vaccine &amp; Infectious Disease Institute 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