{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:18:18Z","timestamp":1781533098155,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microenvironment of a clinically well\u2010characterized prospective cohort (study SAKK35\/10, NCT01307605) of 154 treatment\u2010na\u00efve FL patients in need of therapy, who have been treated with rituximab only or a combination of rituximab and the immunomodulatory drug lenalidomide\/Revlimid\u00ae A high ratio of CD4\u2010 to CD8\u2010positive T cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009) and increased amounts of PD1<jats:sup>+<\/jats:sup> tumour\u2010infiltrating T cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007) were associated with inferior progression\u2010free survival in the whole cohort. Interestingly, the prognostic impact of PD1<jats:sup>+<\/jats:sup> T cells and the CD4\/CD8 ratio lost its significance in the subgroup treated with R<jats:sup>2<\/jats:sup>. In the latter group, high amounts of GATA3<jats:sup>+<\/jats:sup> T helper (Th2) equivalents were associated with better progression\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). We identified tumour microenvironmental features that allow prognostic stratification with respect to immuno\u2010 and combined immuno\u2010 and immunomodulatory therapy. Our analysis indicates that lenalidomide may compensate the adverse prognostic implication of higher amounts of CD4<jats:sup>+<\/jats:sup> and, particularly, PD1<jats:sup>+<\/jats:sup> T cells and that it has favourable effects mainly in cases with higher amounts of Th2 equivalents.<\/jats:p><jats:p>[Correction added on 11 February 2020, after online publication: The NCT\u2010trial number was previously incorrect and has been updated in this version].<\/jats:p>","DOI":"10.1111\/bjh.16414","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T19:28:23Z","timestamp":1580758103000},"page":"707-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-6156","authenticated-orcid":false,"given":"Thomas","family":"Menter","sequence":"first","affiliation":[{"name":"Institute of Pathology and Medical Genetics University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Medical Genetics University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Zucca","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Oncology Institute of Southern Switzerland Bellinzona Switzerland"},{"name":"Institute of Oncology Research Bellinzona Switzerland"},{"name":"Department of Medical Oncology Inselspital \/ Bern University Hospital Bern 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