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Patients received once\u2010daily ibrutinib 560\u00a0mg continuously plus once\u2010weekly rituximab 375\u00a0mg\/m<jats:sup>2<\/jats:sup> for 4\u00a0weeks beginning Week 1 (Arm 1, <jats:italic>n<\/jats:italic>\u00a0=\u00a060) or Week 9 (following an 8\u2010week ibrutinib lead\u2010in) to explore biomarkers (Arm 2, <jats:italic>n<\/jats:italic>\u00a0=\u00a020). The primary endpoint was the best overall response rate (ORR). The median age was 58\u00a0years; most had an Eastern Cooperative Oncology Group Performance Status of 0 (74%) and Stage III\/IV disease (84%). At a median study follow\u2010up of 34\u00a0months in Arm 1 and 29\u00a0months in Arm 2, ORRs were 85% [95% confidence interval (CI) 73\u201393] and 75% (95% CI 51\u201391), respectively, with complete responses in 40% and 50%. The median duration of response was not reached in either arm; 30\u2010month progression\u2010free and overall survival rates were 67% and 97% (Arm 1) and 65% and 100% (Arm 2). The most common adverse events were fatigue, diarrhoea and nausea. Higher grade (Grade 3\/4) haematological, haemorrhagic and cardiac events occurred infrequently. Ibrutinib plus rituximab was active and tolerable in first\u2010line follicular lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.16424","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T04:09:20Z","timestamp":1584418160000},"page":"650-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The combination of ibrutinib and rituximab demonstrates activity in first\u2010line follicular lymphoma"],"prefix":"10.1111","volume":"189","author":[{"given":"Nathan H.","family":"Fowler","sequence":"first","affiliation":[{"name":"University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta","family":"Nastoupil","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"De Vos","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at the University of California Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Knapp","sequence":"additional","affiliation":[{"name":"Zangmeister Cancer Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-290X","authenticated-orcid":false,"given":"Ian W.","family":"Flinn","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Chen","sequence":"additional","affiliation":[{"name":"City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Community Health Network Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-1551","authenticated-orcid":false,"given":"Peter","family":"Martin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Mena","sequence":"additional","affiliation":[{"name":"Providence St. Joseph Medical Center Burbank CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Eric","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sattva S.","family":"Neelapu","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Eckert","sequence":"additional","affiliation":[{"name":"Pharmacyclics LLC, an AbbVie Company Sunnyvale CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Ping","sequence":"additional","affiliation":[{"name":"Pharmacyclics LLC, an AbbVie Company Sunnyvale CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melannie","family":"Co","sequence":"additional","affiliation":[{"name":"Pharmacyclics LLC, an AbbVie Company Sunnyvale CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrin M.","family":"Beaupre","sequence":"additional","affiliation":[{"name":"Pharmacyclics LLC, an AbbVie Company Sunnyvale CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta K.","family":"Neuenburg","sequence":"additional","affiliation":[{"name":"Pharmacyclics LLC, an AbbVie Company Sunnyvale CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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