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To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic\u2010based and population\u2010based lymphoma registries from six countries were used to identify 264 real\u2010world patients. The median age was 47\u00a0years and the majority had advanced\u2010stage disease and elevated LDH. Treatment protocols were R\u2010CODOX\u2010M\/IVAC (47%), R\u2010hyper\u2010CVAD (16%), DA\u2010EPOCH\u2010R (11%), R\u2010BFM\/GMALL (25%) and other (2%) leading to an overall response rate of 89%. The two\u2010year overall survival and event\u2010free survival were 84% and 80% respectively. For patients in complete remission\/unconfirmed, the two\u2010year relapse risk was 6% but diminished to 0\u00b76% for patients reaching 12\u00a0months of post\u2010remission event\u2010free survival (pEFS12). The loss of lifetime for pEFS12 patients was 0\u00b74 (95% CI: \u22120\u00b77 to 2) months. In conclusion, real\u2010world outcomes of adult BL are excellent following intensive immunochemotherapy. For pEFS12 patients, the relapse risk was low and life expectancy similar to that of a general population, which is important information for developing meaningful follow\u2010up strategies with increased focus on survivorship and less focus on routine disease surveillance.<\/jats:p>","DOI":"10.1111\/bjh.16425","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T11:05:20Z","timestamp":1580814320000},"page":"661-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy: an international study of 264 real\u2010world patients"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-7686","authenticated-orcid":false,"given":"Lasse H.","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Hematology 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