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We analysed the <jats:italic>IGHV<\/jats:italic> mutational status in 759 untreated CLL patients (cohort 1). BL\u2010CLL (<jats:italic>n<\/jats:italic>\u00a0=\u00a036, 5%) showed a time to first treatment (TFT) similar to that of M\u2010CLL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0338) and significantly longer than that of UM\u2010CLL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0385), despite the enrichment in subset #2 cases. In fact, CLLs belonging to subset #2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a015\/759, 2%) were significantly more frequent among BL\u2010CLLs (<jats:italic>n<\/jats:italic>\u00a0=\u00a05\/36, 14%), with a brief TFT. TFT of BL\u2010CLL remained comparable to that of M\u2010CLL also considering the 327 CLL patients evaluated at diagnosis. These findings were then validated in an independent cohort 2 of 759 newly diagnosed CLL patients (BL\u2010CLL: <jats:italic>n<\/jats:italic>\u00a0=\u00a011, 1\u00b74%) and in all newly diagnosed patients from cohorts 1 and 2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a01\u00a0086, 84% stage A; BL\u2010CLL: <jats:italic>n<\/jats:italic>\u00a0=\u00a047, 4\u00b73%). BL\u2010CLL at diagnosis showed a biological profile comparable to that of M\u2010CLL with a low frequency of unfavourable prognostic markers, except for a significant enrichment in subset #2. Our data suggest that the prognosis of BL\u2010CLL is good and similar to that of M\u2010CLL, with the exception of subset #2 cases.<\/jats:p>","DOI":"10.1111\/bjh.16434","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T01:23:50Z","timestamp":1581902630000},"page":"853-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-0355","authenticated-orcid":false,"given":"Sara","family":"Raponi","sequence":"first","affiliation":[{"name":"Haematology Department of Translational and Precision Medicine Sapienza University of Rome Rome 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Haematology Unit Department of Haemato\u2010Oncology Ospedale Annunziata Cosenza Italy"},{"name":"Aprigliano Biotechnology Research Unit Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-1101","authenticated-orcid":false,"given":"Giovanna","family":"Cutrona","sequence":"additional","affiliation":[{"name":"Molecular Pathology Unit IRCCS Ospedale Policlinico San Martino Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7393-1138","authenticated-orcid":false,"given":"Riccardo","family":"Moia","sequence":"additional","affiliation":[{"name":"Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont Novara 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