{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:14:20Z","timestamp":1790000060579,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FoU Laboratoriemedicin"},{"name":"Regionala FoU VGR"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>\n<jats:bold>Summary<\/jats:bold>\n<\/jats:title><jats:p>Polycythaemia vera (PV) patients have an overall comparatively favourable prognosis, but disease progression is very heterogeneous and life\u2010threatening thrombosis and bleedings are frequent complications in untreated disease. Moreover, transformation to more severe secondary myelofibrosis and acute myeloid leukaemia can occur. The aim of this study was to identify gene mutations that could be used together with clinical data as prognostic markers to guide treatment decisions in PV patients. A well\u2010characterized WHO\u2010defined cohort of PV patients was used. Clinical data and blood values were evaluated and a myeloid sequencing panel was used to screen for additional mutations other than the diagnostic <jats:italic>JAK2<\/jats:italic> V617F and <jats:italic>JAK2<\/jats:italic> exon 12 mutations. In 78% of the PV patients, at least one mutation additional to <jats:italic>JAK2<\/jats:italic> V617F was detected. Additional mutations in genes coding for epigenetic modifiers, like <jats:italic>TET2<\/jats:italic>, <jats:italic>DNMT3A<\/jats:italic> and <jats:italic>ASXL1<\/jats:italic>, were most frequent. When correlated to overall survival, mutations in <jats:italic>ASXL1<\/jats:italic> were significantly associated with inferior survival. In an attempt to obtain prognostic guidance in a larger number of patients, the presence of <jats:italic>ASXL1<\/jats:italic> mutations was combined with age and vascular complications prior to diagnosis. Based on these data we were able to define three risk groups that predicted survival.<\/jats:p>","DOI":"10.1111\/bjh.16450","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:59:37Z","timestamp":1581987577000},"page":"913-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>ASXL1<\/i> mutations, previous vascular complications and age at diagnosis predict survival in 85 WHO\u2010defined polycythaemia vera patients"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-1331","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Andr\u00e9asson","sequence":"first","affiliation":[{"name":"Hematology Section Department of Medicine NU Hospital Group Uddevalla Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helna","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Hematology Section Department 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