{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:42:33Z","timestamp":1791052953152,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The combined incidence of classical Philadelphia\u2010negative myeloproliferative neoplasm (MPN) is 6\u20139\/100\u00a0000 with a peak frequency between 50 and 70\u00a0years. MPN is less frequent in women of reproductive age. However, for essential thrombocythaemia (ET) in particular there is a second peak in women of reproductive age and 15% of polycythaemia vera (PV) patients are less than 40\u00a0years of age at the time of diagnosis. Thus these diseases are encountered in women of reproductive potential and may be diagnosed in pregnancy or in women being investigated for recurrent pregnancy loss. The incidence of MPN pregnancies is 3\u00b72\/100\u00a0000 maternities per year in the UK. The majority of data regarding Philadelphia\u2010negative MPNs relates to patients with ET, for which the literature suggests significant maternal morbidity and poor fetal outcome; specifically maternal thrombosis and haemorrhage, miscarriage, pre\u2010eclampsia, intrauterine growth restriction (IUGR), stillbirth and premature delivery as summarised in the recent systematic review and meta\u2010analysis in <jats:italic>Blood<\/jats:italic>, 2018, 132, 3046. The literature for PV is more sparse but increasing and is concordant with ET pregnancy outcomes. The literature regarding primary myelofibrosis (PMF) is even more scarce. Treatment options include aspirin, venesection, low molecular weight heparin (LMWH) and cytoreductive therapy. Data and management recommendations are often extrapolated from other pro\u2010thrombotic conditions or from ET to PV and PMF. Women of reproductive age with a diagnosis of MPN should receive information and assurance regarding management and outcome of future pregnancies. From pre\u2010conceptual planning to the post\u2010partum period, women should have access to joint care from an obstetrician with experience of high\u2010risk pregnancies and a haematologist in a multidisciplinary setting. This paper provides an update with regards to Philadelphia\u2010negative MPN in pregnancy, details local practise in an internationally recognised centre for patients with MPN and outlines a future research strategy.<\/jats:p>","DOI":"10.1111\/bjh.16453","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T16:35:30Z","timestamp":1583771730000},"page":"625-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["How we manage Philadelphia\u2010negative myeloproliferative neoplasms in pregnancy"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-5536","authenticated-orcid":false,"given":"Susan E.","family":"Robinson","sequence":"first","affiliation":[{"name":"Haematology Department Guys and St. Thomas' NHS Foundation Trust London 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