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The incidence and risk factors associated with TA\u2010TMA are not well known. A retrospective analysis from the Center for International Blood and Marrow Transplant Research (CIBMTR) was conducted including patients receiving allo\u2010HCT between 2008 and 2016, with the primary objective of evaluating the incidence of TA\u2010TMA. Secondary objectives included identification of risk factors associated with TA\u2010TMA, and the impact of TA\u2010TMA on overall survival and the need for renal replacement therapy (RRT). Among 23,665 allo\u2010HCT recipients, the 3\u2010year cumulative incidence of TA\u2010TMA was 3%. Variables independently\u2010associated with increased incidence of TA\u2010TMA included female sex, prior autologous transplant, primary disease (acute lymphoblastic leukaemia and severe aplastic anaemia), donor type (mismatched or unrelated donor), conditioning intensity (myeloablative), GVHD prophylaxis (sirolimus\u00a0+\u00a0calcineurin inhibitor), pre\u2010transplant kidney dysfunction and acute GVHD (time\u2010varying effect). TA\u2010TMA was associated with higher mortality (HR\u00a0=\u00a03\u00b71, 95% Confidence Interval [CI]\u00a0=\u00a02\u00b78\u201316\u00b73) and RRT requirement (HR\u00a0=\u00a07\u00b71, 95% CI\u00a0=\u00a05\u00b77\u2013311\u00b76). This study provides epidemiologic data on TA\u2010TMA and its impact on transplant outcomes. Increased awareness of the risk factors will enable providers to be vigilant of this uncommon but serious transplant complication. The results will also provide benchmarking for future study designs and comparisons.<\/jats:p>","DOI":"10.1111\/bjh.16457","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T07:16:32Z","timestamp":1583219792000},"page":"1171-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Incidence, Risk Factors for and Outcomes of Transplant\u2010Associated Thrombotic Microangiopathy"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-3457","authenticated-orcid":false,"given":"Narendranath","family":"Epperla","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Medicine The James Cancer Hospital and Solove Research Institute The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"University of Washington Seattle 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