{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:02:02Z","timestamp":1787320922949,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Experimental Cancer Medicine Centre, Birmingham"},{"name":"Clinical Immunology Service at the University of Birmingham"},{"DOI":"10.13039\/100013963","name":"University Hospitals Birmingham NHS Foundation Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013963","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Monoclonal gammopathy of undetermined significance (MGUS) affects 3\u00b72% of adults aged &gt;50\u00a0years. MGUS carries a life\u2010long risk of progression to multiple myeloma and causes complications including infection and renal impairment; common causes of hospital admission. This study aimed to assess MGUS prevalence in emergency medical hospital admissions. Patients were recruited from unselected emergency medical admissions in a hospital in the United Kingdom. Serum protein electrophoresis was performed, with immunofixation of abnormal results. Reason for admission and routine test results were recorded. After education about MGUS and myeloma, patients chose whether they wished to be informed of new diagnoses. A total of 660 patients were tested and 35 had a paraprotein suggestive of MGUS. The overall rate of MGUS was 5\u00b73%. MGUS prevalence in those aged &gt;50\u00a0years was 6\u00b794%, higher than the previously published rate of 3\u00b72% (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b70005). There were higher rates in those with chronic kidney disease (13\u00b775% vs. 4\u00b714%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7002), heart failure (14% vs. 4\u00b759%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7012), anaemia (8\u00b796% vs. 3\u00b741%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7003) or leucocytosis (9\u00b733% vs. 3\u00b704%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7002). In all, 96% of patients wished to be informed of their screening results. The prevalence of MGUS in emergency hospital admissions is higher than expected based on previous population\u2010based rates. This may suggest a selected population for screening.\n                  <\/jats:p>","DOI":"10.1111\/bjh.16487","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T12:06:56Z","timestamp":1580386016000},"page":"1127-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The prevalence and significance of monoclonal gammopathy of undetermined significance in acute medical admissions"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-8515","authenticated-orcid":false,"given":"Catherine","family":"Atkin","sequence":"first","affiliation":[{"name":"Birmingham Acute Care Research Institute of Inflammation and Ageing University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Reddy\u2010Kolanu","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine Queen Elizabeth Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Drayson","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Sapey","sequence":"additional","affiliation":[{"name":"Birmingham Acute Care Research Institute of Inflammation and Ageing University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex G.","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0493-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-5-391"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07807.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08573.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70125-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs.2010.044339"},{"key":"e_1_2_9_8_1","volume-title":"Myeloma Statistics","author":"Cancer Research UK","year":"2017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60482-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04069-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-495929"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-839480"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0080-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-807560"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2014.09.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01075.x"},{"key":"e_1_2_9_18_1","unstructured":"Health and Social Care Information Center(2015).Hospital episode statistics admitted patient care \u2013 England 2014\u201315."},{"key":"e_1_2_9_19_1","first-page":"510","article-title":"Daratumumab monotherapy for patients with intermediate or high\u2010risk smoldering multiple myeloma (SMM): centaurus, a randomized, open\u2010label, multicenter Phase 2 study","volume":"130","author":"Hofmeister C.C.","year":"2017","journal-title":"Blood"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"e_1_2_9_21_1","unstructured":"International Myeloma Working Group(2014)International Myeloma Working Group (IMWG) Criteria for the Diagnosis of Multiple Myeloma [Online].International Myeloma Working Group. 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