{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:16:16Z","timestamp":1792120576596,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"crossref","award":["CAN: 2017\/513"],"award-info":[{"award-number":["CAN: 2017\/513"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Non\u2010Hodgkin lymphoma (NHL) prognosis has improved in recent years, yet the number of patients living with the diagnosis, i.e. the prevalence, has seldom been reported. The prevalence provides a measure of the burden of disease, useful for healthcare planning and to optimise resource allocation. We provide a systematic presentation of temporal trends in absolute numbers of prevalent patients by NHL subtypes, linking them to trends in incidence, survival and mortality. Patients diagnosed 2000\u20132016 were identified in the national Swedish lymphoma register. Incidence and mortality rates, relative survival and prevalence were estimated for NHL overall and for major clinical and morphological subtypes. Poisson regression was used to test for temporal trends. Increasing incidence and improved survival have led to a 47% increase in the five\u2010year prevalence of NHL overall in 2016 compared to 2004. An increasing prevalence was observed for all investigated subtypes during the study period, but most notably for diffuse large B cell lymphomas among aggressive subtypes (66%), and marginal zone lymphomas among indolent subtypes (135%). This dramatic increase in NHL prevalence underscores the need to develop and evaluate alternative follow\u2010up schemes to use resources efficiently and still ensure optimal care of lymphoma survivors.<\/jats:p>","DOI":"10.1111\/bjh.16489","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T10:41:06Z","timestamp":1581936066000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Trends in the prevalence, incidence and survival of non\u2010Hodgkin lymphoma subtypes during the 21st century \u2013 a Swedish lymphoma register study"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-467X","authenticated-orcid":false,"given":"Sara","family":"Ekberg","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicin Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"E. Smedby","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicin Solna Karolinska Institutet Stockholm Sweden"},{"name":"Center for Hematology Karolinska University Hospital Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicin Solna Karolinska Institutet Stockholm Sweden"},{"name":"Department of Immunology, Genetics and Pathology Unit of Clinical Oncology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Nilsson\u2010Ehle","sequence":"additional","affiliation":[{"name":"Section of Hematology and Coagulation Department of Internal Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Goldkuhl","sequence":"additional","affiliation":[{"name":"Department of Oncology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Lewerin","sequence":"additional","affiliation":[{"name":"Section of Hematology and Coagulation Department of Internal Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Department of Oncology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-0573","authenticated-orcid":false,"given":"Sandra","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicin Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.760041"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23722"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14136"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx223"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25147"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0921"},{"key":"e_1_2_8_11_1","first-page":"221","volume-title":"Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, Volume 1: Statistics","author":"Huber P.J.","year":"1967"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.107300"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.0765"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.251"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-019-0126-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28849"},{"key":"e_1_2_8_17_1","first-page":"E36","article-title":"Increasing prevalence of chronic lymphocytic leukemia with an estimated future rise: a nationwide population\u2010based study","volume":"95","author":"Mattsson M.","year":"2019","journal-title":"American Journal of Hematology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.5866"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494816636248"},{"key":"e_1_2_8_20_1","first-page":"33","article-title":"Medellivsl\u00e4ngden \u00f6kar inte lika mycket l\u00e4ngre","volume":"115","author":"Modig K.","year":"2018","journal-title":"Lakartidningen"},{"key":"e_1_2_8_21_1","unstructured":"National Comprehensive Cancer Network. (2019)B\u2010cell Lymphomas (Version 4.2019). Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/b-cell.pdf(Accessed August 23 2019)."},{"key":"e_1_2_8_22_1","unstructured":"National Institute for Health and Care Excellence. (2016)Non\u2010Hodgkin's Lymphoma: Diagnosis and Management NICE guideline: methods evidence and recommendations. Available at:https:\/\/www.nice.org.uk\/guidance\/ng52\/evidence(Accessed December 5 2019)."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"e_1_2_8_24_1","unstructured":"Regionala Cancercentrum i Samverkan. (2019)Nationella kvalitetsregistret f\u00f6r lymfom; \u00c5rsrapport fr\u00e5n Nationell kvalitetsregistret f\u00f6r lymfom diagnosperioden 2000\u20102017. 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