{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:41:54Z","timestamp":1781869314883,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["207"],"award-info":[{"award-number":["207"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Population\u2010based studies that assess long\u2010term patterns of incidence, major aspects of treatment and survival are virtually lacking for Hodgkin lymphoma (HL) at a younger age. This study assessed the progress made for young patients with HL (&lt;25\u00a0years at diagnosis) in the Netherlands during 1990\u20132015. Patient and tumour characteristics were extracted from the population\u2010based Netherlands Cancer Registry. Time trends in incidence and mortality rates were evaluated with average annual percentage change (AAPC) analyses. Stage at diagnosis, initial treatments and site of treatment were studied in relation to observed overall survival (OS). A total of 2619 patients with HL were diagnosed between 1990 and 2015. Incidence rates increased for 18\u201324\u2010year\u2010old patients (AAPC\u00a0+\u00a01%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) only. Treatment regimens changed into less radiotherapy and more \u2018chemotherapy only\u2019, different for age group and stage. Patients aged 15\u201317\u00a0years were increasingly treated at a paediatric oncology centre. The 5\u2010year OS for children was already high in the early 1990s (93%). For patients aged 15\u201317 and 18\u201324\u00a0years the 5\u2010year OS improved from 84% and 90% in 1990\u20131994 to 96% and 97% in 2010\u20132015, respectively. Survival for patients aged 15\u201317\u00a0years was not affected by site of treatment. Our present data demonstrate that significant progress in HL treatment has been made in the Netherlands since 1990.<\/jats:p>","DOI":"10.1111\/bjh.16491","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T03:35:51Z","timestamp":1581046551000},"page":"1093-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Improved survival for adolescents and young adults with Hodgkin lymphoma and continued high survival for children in the Netherlands: a population\u2010based study during 1990\u20132015"],"prefix":"10.1111","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-9957","authenticated-orcid":false,"given":"Ardine M. J.","family":"Reedijk","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline A. 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Michel","family":"Zwaan","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"},{"name":"Dutch Childhood Oncology Group Utrecht the Netherlands"},{"name":"Department of Pediatric Oncology\/Hematology Erasmus University Medical Center Sophia Children\u2019s Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert O. R.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"},{"name":"Department of Radiation Oncology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-9460","authenticated-orcid":false,"given":"Wouter J.","family":"Plattel","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4767-6716","authenticated-orcid":false,"given":"Avinash G.","family":"Dinmohamed","sequence":"additional","affiliation":[{"name":"Department of Research Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9e M.","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Department of Hematology location VU Medical Center Amsterdam UMC Cancer Center Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C. 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