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However, its potential role in adults with B cell acute lymphoblastic leukaemia (ALL) is unknown. We found that in adults with common B cell ALL high <jats:italic>DPEP1,<\/jats:italic> transcript levels at diagnosis were independently associated with an increased cumulative incidence of relapse (CIR) and worse relapse\u2010free survival (RFS) compared with subjects with low transcript levels. We show an increased proliferation and prosurvival role of <jats:italic>DPEP1<\/jats:italic> in B cell ALL cells <jats:italic>via<\/jats:italic> regulation of phosphCREB and p53, which may be the biological basis of the clinical correlation we report. Our data implicate <jats:italic>DPEP1<\/jats:italic> expression in the biology of common B cell ALL in adults. We report clinical correlates and provide a potential biological basis for these correlations. If confirmed, analysing <jats:italic>DPEP1<\/jats:italic> transcript levels at diagnosis could help predict therapy outcomes. Moreover, regulation of <jats:italic>DPEP1<\/jats:italic> expression could be a therapy target in B cell ALL.<\/jats:p>","DOI":"10.1111\/bjh.16505","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T11:40:40Z","timestamp":1582026040000},"page":"67-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"190","author":[{"given":"Jia\u2010Min","family":"Zhang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Collaborative Innovation Center of Hematology Peking University People's Hospital Peking University Institute of Hematology Beijing 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