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While not associated with any impact on life expectancy, it has been established that SCT is associated with an increased risk of both venous thromboembolism (and in particular, pulmonary embolism) and chronic kidney disease. It is largely unknown what short\u2010 or long\u2010term effect, if any, pregnancy has upon the risk or outcomes of these disorders. In addition, SCT has been linked with various adverse outcomes in pregnancy, ranging from maternal complications such as elevated risk of bacteriuria to potentially life\u2010threatening entities such as pre\u2010eclampsia and prematurity. In these scenarios also, no clear association with SCT has been established. Given the high worldwide prevalence of SCT, further studies addressing these issues are warranted.<\/jats:p>","DOI":"10.1111\/bjh.16518","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T09:04:40Z","timestamp":1581930280000},"page":"328-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pregnancy in sickle cell trait: what we do and don\u2019t know"],"prefix":"10.1111","volume":"190","author":[{"given":"Samuel","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of Pediatrics University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"UNC Blood Research Center University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ellsworth","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of Pediatrics University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"UNC Blood Research Center University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-4304","authenticated-orcid":false,"given":"Nigel S.","family":"Key","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"UNC Blood Research Center University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of Laboratory Medicine and Pathology University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(96)90113-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200701000-00055"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4857.290"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200004)63:4<205::AID-AJH8>3.0.CO;2-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057604"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.038"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-356"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(90)90649-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1007639"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000258275.24990.9c"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2013.832689"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1963.03860020120016"},{"key":"e_1_2_9_14_1","first-page":"15","article-title":"Newborn screening for sickle cell disease in Europe","volume":"5","author":"Daniel Y.","year":"2019","journal-title":"International Journal of Network Science"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070705"},{"key":"e_1_2_9_16_1","unstructured":"Derebail V.K. 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