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We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45<jats:sup>+<\/jats:sup> and CD3<jats:sup>+<\/jats:sup> compartments. Double positive T cells and PD\u20101 positive CD4 T cells were expanded and na\u00efve CD4 T cells were decreased in the bone marrow of patients with newly diagnosed\/progressing POEMS. These findings provide evidence for possible antigenic\u2010driven selection as a driver of disease pathogenesis in POEMS.<\/jats:p>","DOI":"10.1111\/bjh.16522","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T05:03:51Z","timestamp":1582261431000},"page":"79-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-9434","authenticated-orcid":false,"given":"Taxiarchis V.","family":"Kourelis","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN 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