{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:36Z","timestamp":1787013936704,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    For patients with untreated hepatic veno\u2010occlusive disease (VOD)\/sinusoidal obstruction syndrome (SOS) with multi\u2010organ dysfunction (MOD), mortality is &gt;80%. We conducted a pooled analysis of three studies that assessed Day 100 survival in relationship to MOD severity, with dialysis and\/or ventilator dependence representing the most severe organ dysfunction. All patients in the analysis were diagnosed using Baltimore criteria\/biopsy. This analysis of patients with VOD\/SOS and MOD after haematopoietic cell transplantation (HCT;\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a0651) demonstrated higher Day 100 survival rates amongst defibrotide\u2010treated patients with VOD\/SOS with less\n                    <jats:italic>versus<\/jats:italic>\n                    more severe forms of MOD. Even patients with severe forms of MOD post\u2010HCT benefitted from defibrotide.\n                  <\/jats:p>","DOI":"10.1111\/bjh.16552","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T22:15:01Z","timestamp":1583878501000},"page":"583-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pooled analysis of Day 100 survival for defibrotide\u2010treated patients with hepatic veno\u2010occlusive disease\/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-8865","authenticated-orcid":false,"given":"Paul G.","family":"Richardson","sequence":"first","affiliation":[{"name":"Division of Hematologic Malignancy Department of Medical Oncology Jerome Lipper Multiple Myeloma Center Harvard Medical School Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Pediatric Blood and Marrow Transplantation University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Kernan","sequence":"additional","affiliation":[{"name":"Pediatric BMT Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancy Department of Medical Oncology Center for Stem Cell Transplantation Harvard Medical School Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Soiffer","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancy Harvard Medical School Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals, Inc. 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