{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:54:19Z","timestamp":1761897259235,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["CKTO 2006\u201007"],"award-info":[{"award-number":["CKTO 2006\u201007"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rituximab\u2010containing induction followed by autologous stem cell transplantation (ASCT) is the standard first\u2010line treatment for young mantle cell lymphoma patients. However, most patients relapse after ASCT. We investigated in a randomised phase II study the outcome of a chemo\u2010immuno regimen and ASCT with or without maintenance therapy with bortezomib. Induction consisted of three cycles R\u2010CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), two cycles high\u2010dose cytarabine, BEAM (carmustine, etoposide, cytarabine, melphalan) and ASCT. Patients responding were randomised between bortezomib maintenance (1\u00b73\u00a0mg\/m<jats:sup>2<\/jats:sup> intravenously once every 2 weeks, for 2\u00a0years) and observation. Of 135 eligible patients, 115 (85%) proceeded to ASCT, 60 (44%) were randomised. With a median follow\u2010up of 77\u00b75\u00a0months for patients still alive, 5\u2010year event\u2010free survival (EFS) was 51% (95% CI 42\u201359%); 5\u2010year overall survival (OS) was 73% (95% CI 65\u201380%). The median follow\u2010up of randomised patients still alive was 71\u00b75\u00a0months. Patients with bortezomib maintenance had a 5\u2010year EFS of 63% (95% CI 44\u201378%) and 5\u2010year OS of 90% (95% CI 72\u201397%). The patients randomised to observation had 5\u2010year PFS of 60% (95% CI, 40\u201375%) and OS of 90% (95% CI 72\u201397%). In conclusion, in this phase II study we found no indication of a positive effect of bortezomib maintenance after ASCT.<\/jats:p>","DOI":"10.1111\/bjh.16567","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T13:02:59Z","timestamp":1583758979000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bortezomib maintenance after R\u2010CHOP, cytarabine and autologous stem cell transplantation in newly diagnosed patients with mantle cell lymphoma, results of a randomised phase II HOVON trial"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-0918","authenticated-orcid":false,"given":"Jeanette K.","family":"Doorduijn","sequence":"first","affiliation":[{"name":"Haematology Erasmus MC Cancer Centre Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josee M.","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Amsterdam UMC \u2013 Locatie VUMC Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-8651","authenticated-orcid":false,"given":"Pieternella J.","family":"Lugtenburg","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Centre Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Josee","family":"Kersten","sequence":"additional","affiliation":[{"name":"Haematology Amsterdam UMC University of Amsterdam Cancer Center Amsterdam and LYMMCARE (lymphoma and myeloma Center) Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara H.","family":"B\u00f6hmer","sequence":"additional","affiliation":[{"name":"Haematology Haga Teaching Hospital The Hague USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique C.","family":"Minnema","sequence":"additional","affiliation":[{"name":"Haematology UMC Utrecht Cancer Centre Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius A.","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"UMCN Nijmegen Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rien","family":"van Marwijk Kooij","sequence":"additional","affiliation":[{"name":"Internal Medicine Isala Clinic Zwolle Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"de Jongh","sequence":"additional","affiliation":[{"name":"Albert Schweitzer Hospital Location Dordwijk Dordrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjeerd J.F.","family":"Snijders","sequence":"additional","affiliation":[{"name":"Medisch Spectrum Twente Enschede Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okke","family":"de 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