{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:34:07Z","timestamp":1790393647392,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007311","name":"Deutsche Kinderkrebsstiftung","doi-asserted-by":"publisher","award":["DKS 2014.11 A\/B"],"award-info":[{"award-number":["DKS 2014.11 A\/B"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["91691153"],"award-info":[{"award-number":["91691153"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Large B\u2010cell lymphoma with <jats:italic>IRF4<\/jats:italic> rearrangement, and Burkitt\u2010like lymphoma with 11q aberration are two provisional lymphoma entities in the 2017 revision of the WHO classification of lymphoid neoplasms. Despite being more frequent in young patients, knowledge regarding their true incidence and clinical features in unselected cohorts of paediatric and adolescent patients is limited. We screened for both entities among paediatric patients (&lt;18\u00a0years of age) in the German NHL\u2010BFM (Non\u2010Hodgkin lymphoma Berlin\u2010Frankfurt\u2010M\u00fcnster) group. Among follicular lymphomas and diffuse large B\u2010cell lymphomas (DLBCL), 7\/34 cases (21%) showed an <jats:italic>IRF4<\/jats:italic> break\u2010apart pattern by fluorescence <jats:italic>in situ<\/jats:italic> hybridisation (FISH) and are associated with stages I and II disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7043). Among lymphomas morphologically resembling Burkitt lymphoma, DLBCL and high\u2010grade B\u2010cell lymphoma, unclassifiable, 13\/102 cases (13%) lacked a <jats:italic>MYC<\/jats:italic> break\u2010apart pattern but were positive for 11q proximal gain and telomeric loss by FISH. <jats:italic>MYC<\/jats:italic>\u2010negative Burkitt\u2010like lymphomas with the typical 11q gain\u2010loss pattern by FISH were older (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004), showed less male predominance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003), lower stage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7040), lower serum LDH level (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) and less abdominal involvement (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008) compared to high grade B\u2010cell lymphomas without 11q gain\u2010loss pattern. Both entities showed excellent outcome with overall survival of 100% when managed according to NHL\u2010BFM strategies and may provide candidates for future therapy de\u2010escalation in clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.16578","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T11:20:50Z","timestamp":1585826450000},"page":"753-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Experience with provisional WHO\u2010entities large B\u2010cell lymphoma with <i>IRF4<\/i>\u2010rearrangement and Burkitt\u2010like lymphoma with 11q aberration in paediatric patients of the NHL\u2010BFM group"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3137-0886","authenticated-orcid":false,"given":"Rex K. H.","family":"Au\u2010Yeung","sequence":"first","affiliation":[{"name":"Department of Pathology, Hematopathology Section University Hospital Schleswig\u2010Holstein Christian\u2010Albrecht\u2010University of Kiel Kiel Germany"},{"name":"Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Arias Padilla","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology University Children's Hospital M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Hannover Medical School Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section University Hospital Schleswig\u2010Holstein Christian\u2010Albrecht\u2010University of Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University &amp; Ulm University Medical Center Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Woessmann","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology University Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-829X","authenticated-orcid":false,"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology University Children's Hospital M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-4117","authenticated-orcid":false,"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section University Hospital Schleswig\u2010Holstein Christian\u2010Albrecht\u2010University of Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330795"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-507996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27770"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207928"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-864025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14812"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.230"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx139"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.186"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05735.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.124305"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002699"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018023572"},{"key":"e_1_2_8_16_1","article-title":"Cryptic insertion of MYC exons 2 and 3 into the IGH locus detected by whole genome sequencing in a case of MYC\u2010negative Burkitt lymphoma","volume":"104","author":"Wagener R","year":"2019","journal-title":"Haematologica"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.16578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.16578","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:57:00Z","timestamp":1693328220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.16578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/bjh.16578"],"URL":"https:\/\/doi.org\/10.1111\/bjh.16578","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]},"assertion":[{"value":"2019-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}