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In addition to patient\u2010 and disease\u2010related factors, toxicity associated with HCT puts patients at risk for complications that share a similar pathophysiology involving endothelial cells (ECs). Normally, the endothelium plays a role in maintaining homeostasis, including regulation of coagulation, vascular tone, permeability and inflammatory processes. When activated, ECs acquire cellular features that may lead to phenotypic changes that induce procoagulant, pro\u2010inflammatory and pro\u2010apoptotic mediators leading to EC dysfunction and damage. 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