{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:34:04Z","timestamp":1789500844469,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We studied the efficacy and safety of humanized CAR\u2010T therapy following intensive chemotherapy for refractory\/relapsed (R\/R) acute lymphoblastic leukaemia (B\u2010ALL). Twenty\u2010three patients with R\/R B\u2010ALL were pretreated with intensive chemotherapy (fludarabine combined with medium\u2010dose cytarabine) 12\u00a0days before CAR\u2010T therapy. Adverse events (AEs), curative effects, infection indicators and cytokine release syndrome (CRS) were monitored. Each of the 23 patients received a dose of 1\u00b70\u00a0\u00d7\u00a010\n                    <jats:sup>6<\/jats:sup>\n                    cells\/kg CAR\u2010T cell infusion on day 0. After 14\u00a0days, 19 patients (82\u00b761%) achieved complete response (CR) or CR with incomplete count recovery. No survival benefit was achieved with consolidative haematopoietic stem\u2010cell transplantation (HSCT), with a median follow\u2010up of 14\u00b70\u00a0months (range, 1\u00b75\u201321\u00b70\u00a0months). The notable AEs were grade 1\u20132 CRS in 18 patients, while the other five patients were grade 3 CRS. No patients died of CRS. Only one patient died of respiratory failure due to cytomegalovirus infection 24\u00a0days after infusion. The proportion of leukaemic cells in bone marrow on infusion day and the peaks of IL\u20106, TNF\u2010\u03b1 and IL\u20108 levels were correlated with CRS levels. A lower disease burden was achieved by intensive lymphodepleting chemotherapy, and the subsequent CAR\u2010T therapy had a high response and manageable toxicity.\n                  <\/jats:p>\n                  <jats:p>Trial registration: The patients were enrolled in a clinical trial of ChiCTR\u2010ONN\u201016009862, and ChiCTR1800019622.<\/jats:p>","DOI":"10.1111\/bjh.16623","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T04:22:39Z","timestamp":1585628559000},"page":"212-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Efficacy and safety of humanized anti\u2010CD19\u2010CAR\u2010T therapy following intensive lymphodepleting chemotherapy for refractory\/relapsed B acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-6948","authenticated-orcid":false,"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Mou","sequence":"additional","affiliation":[{"name":"Shanghai Genbase Biotechnology Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Genbase Biotechnology Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-0567","authenticated-orcid":false,"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanxia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology City of Hope National Medical Center Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-4953","authenticated-orcid":false,"given":"Qi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital Tianjin 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