{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:39:38Z","timestamp":1772811578831,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011068","name":"Fondation Saint-Luc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011068","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Fund for Scientific Research"},{"name":"Fonds de Recherche des Cliniques Universitaires Saint-Luc"},{"name":"Association pour l\u2019Information et la Recherche sur les Maladies R\u00e9nales G\u00e9n\u00e9tiques"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pregnancy has been linked to various microangiopathies, including primary atypical haemolytic uraemic syndrome (aHUS). Complement dysregulation, often linked to rare variants in complement genes, is key for primary aHUS to manifest and may play a role in pregnancy complications of the mother and fetus. The burden of such complications is unknown, making counselling of women with primary aHUS and asymptomatic relatives difficult. We analyzed the maternal and fetal outcomes of 39 pregnancies from 17 women with primary aHUS and two asymptomatic relatives. Seven out of 39 pregnancies were complicated by pregnancy\u2010associated aHUS. Five out of 32 pregnancies not linked to pregnancy\u2010associated aHUS were complicated by pre\u2010eclampsia or HELLP. Rare genetic variants were identified in 10 women (asymptomatic relatives, <jats:italic>n<\/jats:italic>\u00a0=\u00a02) who had a total of 14 pregnancies, including 10 uncomplicated pregnancies. Thirty\u2010five out of 39 pregnancies resulted in live birth. Eight out of 19 women had progressed to end\u2010stage kidney disease, with an incidence of 2\u00b795 (95% confidence interval, 1\u00b737\u20135\u00b761) per 100 person\u2010years after the first pregnancy. Thus, we emphasized the frequency of successful pregnancies in women with primary aHUS and asymptomatic relatives. Pregnancies should be monitored closely. Rare genetic variants cannot predict the risk of a given pregnancy.<\/jats:p>","DOI":"10.1111\/bjh.16626","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T04:11:11Z","timestamp":1588047071000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The natural course of pregnancies in women with primary atypical haemolytic uraemic syndrome and asymptomatic relatives"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-2753","authenticated-orcid":false,"given":"Sjoerd A. M. E. G.","family":"Timmermans","sequence":"first","affiliation":[{"name":"Department of Nephrology and Clinical Immunology Maastricht University Medical Center Maastricht the Netherlands"},{"name":"Department of Biochemistry Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Werion","sequence":"additional","affiliation":[{"name":"Division of Nephrology Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc E. A.","family":"Spaanderman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Center Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris P.","family":"Reutelingsperger","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G. M. C.","family":"Damoiseaux","sequence":"additional","affiliation":[{"name":"Department of Central Diagnostic Laboratory Maastricht University Medical Center Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Morelle","sequence":"additional","affiliation":[{"name":"Division of Nephrology Cliniques Universitaires Saint\u2010Luc Brussels Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique UCLouvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"van Paassen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Immunology Maastricht University Medical Center Maastricht the Netherlands"},{"name":"Department of Biochemistry Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070706"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04760512"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02210310"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144691"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99128"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00262"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.498"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00280117"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13121211"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016090995"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00835.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2012.11.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.65"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.12.023"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701695"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq658"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004050380"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-558296"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018020184"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497779"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2011.00671.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.04.009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.04.011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw314"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706790"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020255"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.12.034"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.423"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408914"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.022"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402220"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220635"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.16626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.16626","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:37:54Z","timestamp":1693409874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.16626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/bjh.16626"],"URL":"https:\/\/doi.org\/10.1111\/bjh.16626","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]},"assertion":[{"value":"2020-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}