{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:40:11Z","timestamp":1787312411940,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["T32 HG008341"],"award-info":[{"award-number":["T32 HG008341"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Immunomodulatory drugs (IMiDs) have improved survival of patients with multiple myeloma (MM) and comprise the therapeutic backbone at all phases of therapy. Although well\u2010tolerated, IMiDs increase rates of venous thromboembolism (VTE). In this phase IV, single\u2010arm pilot study, fifty patients with MM on IMiDs received apixaban 2\u00b75\u00a0mg orally twice daily for primary prevention of VTE and were prospectively monitored for six\u00a0months. The primary safety outcomes were rates of major haemorrhage and clinically relevant non\u2010major haemorrhage over six\u00a0months. The primary efficacy outcome was the rate of symptomatic VTE over six\u00a0months. IMiDs used were lenalidomide (58%) or pomalidomide (42%). During the six\u2010month evaluation period, no patients experienced major haemorrhage or VTE. Three patients experienced clinically relevant, non\u2010major haemorrhage which was managed medically, and all were able to resume apixaban. One patient stopped therapy shortly after initiation due to an allergic reaction to apixaban. No patients experienced stroke, myocardial infarction, or death. In this pilot study, low\u2010dose apixaban was safe and well\u2010tolerated as a primary prevention therapy of VTE for patients with MM receiving IMiDs. Further studies are needed to validate low\u2010dose apixaban as a standard primary prevention anti\u2010thrombotic strategy for patients with MM receiving IMiDs.<\/jats:p>","DOI":"10.1111\/bjh.16653","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T03:36:25Z","timestamp":1587440185000},"page":"555-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Primary prevention of venous thromboembolism with apixaban for multiple myeloma patients receiving immunomodulatory agents"],"prefix":"10.1111","volume":"190","author":[{"given":"Robert F.","family":"Cornell","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Z.","family":"Goldhaber","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular 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