{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:54:23Z","timestamp":1774893263065,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Splenectomy is considered therapeutic in various non\u2010malignant haematologic diseases. Adverse events \u2012 specifically infections and thromboembolism \u2012 are not extensively documented in the paediatric population, maintaining the concern over risks\u2010versus\u2010benefits of the procedure. We studied a cohort of paediatric haematology patients undergoing splenectomy between 1977 and 2015 to determine short\u2010 and long\u2010term complications. We summarised all the patients of the haematology clinic in our major Israeli tertiary centre undergoing splenectomy for therapeutic reasons, capturing infectious and thromboembolic events. The data of 103 patients, comprising 1657 follow\u2010up years, were analysed. The cohort included 33 patients with transfusion\u2010dependent thalassaemia, seven with non\u2010transfusion\u2010dependent thalassaemia, four with sickle\u2010thalassaemia, 41 with hereditary spherocytosis, and 18 with immune thrombocytopenia. Standard presplenectomy vaccinations were noted in most. No typical cases of overwhelming postsplenectomy infection (OPSI) were identified, nor were typical OPSI bacteria isolated. Thalassaemics with central lines were most prone to infection and thrombosis. Beyond this subgroup, thrombotic events were anecdotal. This is the largest study to date to comprehensively analyse infectious and thrombotic complications of childhood splenectomy for the treatment of haematologic diseases. The use of splenectomy appears to be a relatively safe therapeutic option in paediatric patients with proper preoperative vaccination and follow\u2010up care; use of central venous lines or catheters increase the risk in thalassaemic patients and should be avoided if possible.<\/jats:p>","DOI":"10.1111\/bjh.16657","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T08:47:45Z","timestamp":1588063665000},"page":"909-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Splenectomy in childhood for non\u2010malignant haematologic disorders \u2013 long\u2010term follow\u2010up shows minimal adverse effects"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-5694","authenticated-orcid":false,"given":"Joanne","family":"Yacobovich","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Oncology Schneider Children's Medical Center of Israel Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-0556","authenticated-orcid":false,"given":"Shlomit","family":"Barzilai\u2010Birenboim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology Schneider Children's Medical Center of Israel Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-2388","authenticated-orcid":false,"given":"Orna","family":"Steinberg\u2010Shemer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology Schneider Children's Medical Center of Israel Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinhas","family":"Stark","sequence":"additional","affiliation":[{"name":"The Comprehensive Center of Thalassemia, Hemoglobinopathies &amp; Rare Anemias Institute of Hematology Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idit","family":"Pazgal","sequence":"additional","affiliation":[{"name":"The Comprehensive Center of Thalassemia, Hemoglobinopathies &amp; Rare Anemias Institute of Hematology Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Tamary","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Molecular Diagnostic Laboratory Felsenstein Medical Research Center  Sackler School of Medicine Tel Aviv University Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2001.0904"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600867743"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61493-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655400458811"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195208000-00006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196706012762203"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08843.x"},{"key":"e_1_2_6_9_1","first-page":"2","article-title":"OPSI threat in hematological patients","volume":"6","author":"Serio B","year":"2013","journal-title":"Transl Med UniSa"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V15.2.197.197"},{"key":"e_1_2_6_11_1","unstructured":"KimberlinDW. 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