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We analyzed 492 adult patients undergoing human leucocyte antigen (HLA)\u2010matched sibling or unrelated donor allo\u2010HCT for HL between 2008 and 2016, utilizing RIC with either fludarabine\/busulfan (Flu\/Bu), fludarabine\/melphalan (Flu\/Mel140) or fludarabine\/cyclophosphamide (Flu\/Cy). Multivariable regression analysis was performed using a significance level of &lt;0\u00b701. There were no significant differences between regimens in risk for non\u2010relapse mortality (NRM) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b754), relapse\/progression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702) or progression\u2010free survival (PFS) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b714). Flu\/Cy conditioning was associated with decreased risk of mortality in the first 11\u00a0months after allo\u2010HCT (HR\u00a0=\u00a00\u00b728; 95% CI\u00a0=\u00a00\u00b710\u20130\u00b773; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009), but beyond 11\u00a0months post allo\u2010HCT it was associated with a significantly higher risk of mortality, (HR\u00a0=\u00a02\u00b746; 95% CI\u00a0=\u00a00\u00b71.32\u20134\u00b761; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005). Four\u2010year adjusted overall survival (OS) was similar across regimens at 62% for Flu\/Bu, 59% for Flu\/Mel140 and 55% for Flu\/Cy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b764), respectively. These data confirm the choice of RIC for allo\u2010HCT in HL does not influence risk of relapse, NRM or PFS. Although no OS benefit was seen between Flu\/Bu and Flu\/Mel 140; Flu\/Cy was associated with a significantly higher risk of mortality beyond 11\u00a0months from allo\u2010HCT (possibly due to late NRM events).<\/jats:p>","DOI":"10.1111\/bjh.16664","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T10:01:27Z","timestamp":1587463287000},"page":"573-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Impact of type of reduced\u2010intensity conditioning regimen on the outcomes of allogeneic haematopoietic cell transplantation in classical Hodgkin lymphoma"],"prefix":"10.1111","volume":"190","author":[{"given":"Sairah","family":"Ahmed","sequence":"first","affiliation":[{"name":"MD Anderson Cancer Center University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology and Blood Disorders Levine Cancer Institute Atrium Health Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang W.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Medicine CIBMTR\u00ae (Center for International Blood and Marrow Transplant Research) Medical College of Wisconsin Milwaukee WI USA"},{"name":"Division of Biostatistics Institute for Health and Equity Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Khanal","sequence":"additional","affiliation":[{"name":"Department of Medicine CIBMTR\u00ae (Center for International Blood and Marrow Transplant Research) Medical College of Wisconsin Milwaukee WI 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