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Based on data from the Cancer Registry of Norway, we investigated trends in incidence and relative survival (RS) for 10\u00a0524 patients in three age groups diagnosed between 1982 and 2017. Nationwide myeloma drug consumption statistics were obtained from the Norwegian Institute of Public Health. Patients aged &lt;65\u00a0years had a steady increase in both 5\u2010 and 10\u2010year RS across all calendar periods from 1982. For patients aged 65\u201379\u00a0years, RS was stable until the calendar period 1998\u20132002, followed by an improvement in both 5\u2010 and 10\u2010year RS. The 5\u2010year RS for patients aged \u226580\u00a0years also increased significantly between the first and the last calendar period. In conclusion, we demonstrate a significant improvement in 5\u2010year RS in all age groups. Improved RS in patients aged \u226580\u00a0years at the time of diagnosis is only rarely described in other population\u2010based studies. For patients aged \u226565\u00a0years, the improvement in RS coincides with the introduction of modern drugs, whereas patients aged &lt;65\u00a0years had an ongoing improvement before the introduction of autologous stem\u2010cell transplant.<\/jats:p>","DOI":"10.1111\/bjh.16674","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T07:58:39Z","timestamp":1588665519000},"page":"418-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Incidence and survival of multiple myeloma: a population\u2010based study of 10\u00a0524 patients diagnosed 1982\u20132017"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-7086","authenticated-orcid":false,"given":"\u00d8ystein O.","family":"Langseth","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim 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