{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:58:26Z","timestamp":1781585906846,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Platelet counts are decreased in <jats:italic>Plasmodium falciparum<\/jats:italic> malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2\u00a0248 controls enrolled in a case\u2010control study in Uganda, Tanzania and Kenya (2010\u20132016). Mean platelet counts in controls\u00a0or eBL cases with or without\u00a0malaria\u2010infection in controls versus eBLcases\u00a0were compared using Student\u2019s <jats:italic>t<\/jats:italic>\u2010test. Odds ratios (ORs) and two\u2010sided 95% confidence intervals (95% CIs) were estimated using multiple logistic regression, controlling for age, sex, haemoglobin and white blood cell counts. Platelets were decreased with malaria infection in the controls [263 vs. 339\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> platelets\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001; adjusted OR (aOR)\u00a0=\u00a03\u00b742, 95% CI: 2\u00b779\u20134\u00b718] and eBL cases (314 vs. 367\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> platelets\/l, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b7002; aOR\u00a0=\u00a02\u00b736, 95% CI: 1\u00b749\u20133\u00b773). Unexpectedly, platelets were elevated in eBL cases <jats:italic>versus<\/jats:italic> \u00a0controls in overall analyses (mean: 353 vs. 307\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> platelets\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001; aOR\u00a0=\u00a01\u00b741; 95% CI: 1\u00b712\u20131\u00b777), and when restricted\u00a0to malaria\u2010positive (mean 314 vs. 263\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> platelets\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001; OR\u00a0=\u00a02\u00b726; 95% CI: 1\u00b756\u20133\u00b727) or malaria\u2010negative (mean 367 vs. 339\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> platelets\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001; OR\u00a0=\u00a01\u00b746; 95% CI: 1\u00b717\u20131\u00b783) subjects. Platelets were decreased with malaria infection in controls and eBL cases but elevated with eBL.<\/jats:p>","DOI":"10.1111\/bjh.16700","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T17:52:58Z","timestamp":1589305978000},"page":"772-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya"],"prefix":"10.1111","volume":"190","author":[{"given":"Sally","family":"Peprah","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Ogwang","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study St. Mary\u2019s Hospital Lacor, Gulu &amp; African Field Epidemiology Network Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kerchan","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Kuluva Hospital Arua &amp; African Field Epidemiology Network Kuluva Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance N.","family":"Tenge","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Moi University College of Health Sciences Eldoret Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Were","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Academic Model Providing Access To Healthcare Eldoret Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Kuremu","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Moi University College of Health Sciences Eldoret Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter N","family":"Wekesa","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Moi University College of Health Sciences Eldoret Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestory","family":"Masalu","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Bugando Medical Center Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kawira","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Shirati Health, Education, and Development Foundation, and Shirati Hospital Shirati Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kinyera","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study St. Mary\u2019s Hospital Lacor, Gulu &amp; African Field Epidemiology Network Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Otim","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study St. Mary\u2019s Hospital Lacor, Gulu &amp; African Field Epidemiology Network Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail D.","family":"Legason","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Kuluva Hospital Arua &amp; African Field Epidemiology Network Kuluva Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadijah","family":"Nabalende","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study St. Mary\u2019s Hospital Lacor, Gulu &amp; African Field Epidemiology Network Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herry","family":"Dhudha","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Shirati Health, Education, and Development Foundation, and Shirati Hospital Shirati Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mediatrix","family":"Mumia","sequence":"additional","affiliation":[{"name":"EpideMiology of Burkitt Lymphoma in East African Children and Minors Study Academic Model Providing Access To Healthcare Eldoret Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona W.","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Biggar","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Goedert","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-9831","authenticated-orcid":false,"given":"Sam M.","family":"Mbulaiteye","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-019-0236-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70125-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1089"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.09.037"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-475665"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0551"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0191"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228892"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.00031.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-018-0170-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-849307"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166296"},{"key":"e_1_2_8_16_1","first-page":"131","article-title":"The role of platelets in infections. 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