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In the MCL01 trial, patients were treated with the R\u2010HCVAD regimen [rituximab plus HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone; R\u2010CVAD) alternating with high\u2010dose methotrexate and cytarabine (AM)] for four cycles followed by autologous stem cell transplantation (ASCT) for those who reached only a partial response. After a median follow\u2010up of 10\u00b75\u00a0years, we reported 10\u2010year progression\u2010free and overall survival rates of 35% and 61% respectively, with a 10\u2010years cumulative incidence rate of second malignancies of 10\u00b76%. Mature results of the MCL01 trial confirmed the efficacy of HyperCVAD\u2010AM as a frontline regimen for younger patients (\u226465\u00a0years).<\/jats:p>","DOI":"10.1111\/bjh.16714","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T05:53:46Z","timestamp":1589522026000},"page":"1011-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term results of the MCL01 phase II trial of rituximab plus HyperCVAD alternating with high\u2010dose cytarabine and methotrexate for the initial treatment of patients with mantle cell lymphoma"],"prefix":"10.1111","volume":"192","author":[{"given":"Fulvio","family":"Massaro","sequence":"first","affiliation":[{"name":"Hematology AUSL\/IRCCS Reggio Emilia Reggio Emilia Italy"},{"name":"PhD Program in Clinical and Experimental Medicine University of Modena and Reggio Emilia 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