{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:43:32Z","timestamp":1792280612289,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004267","name":"Royal Adelaide Hospital","doi-asserted-by":"publisher","award":["Contributing Haematologists Committee"],"award-info":[{"award-number":["Contributing Haematologists Committee"]}],"id":[{"id":"10.13039\/501100004267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1059165"],"award-info":[{"award-number":["APP1059165"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1138935"],"award-info":[{"award-number":["APP1138935"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    There is currently no biomarker that reliably predicts treatment\u2010free remission (TFR) in chronic myeloid leukaemia (CML). We characterised effector and suppressor immune responses at the time of tyrosine kinase inhibitor (TKI) cessation in patients from the CML8 and CML10 clinical studies. Natural killer (NK) cells with increased expression of activating NK receptors were higher in patients who achieved TFR. There was no difference in the proportion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    or CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Furthermore, we found that FoxP3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (T reg) and monocytic myeloid\u2010derived suppressor cells (Mo\u2010MDSCs) were concomitantly decreased in TFR patients, suggesting that the effector and suppressor arms of the immune system work in concert to mediate TFR. A discovery cohort (CML10) was used to generate a predictive model, using logistic regression. Patients classified into the high\u2010risk group were more likely to relapse when compared with the low\u2010risk group (HR 7\u00b74, 95% CI 2\u00b79\u201019\u00b71). The model was successfully validated on the independent CML8 cohort (HR 8\u00b73, 95% CI 2\u00b72\u201331\u00b73). Effective prediction of TFR success may be obtained with an effector\u2010suppressor score, calculated using absolute NK cell, T reg, and Mo\u2010MDSC counts, at TKI cessation, reflecting the contribution of both immune suppressors and effectors in the immunobiology underlying successful TFR.\n                  <\/jats:p>","DOI":"10.1111\/bjh.16718","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T14:28:31Z","timestamp":1588256911000},"page":"433-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Successful treatment\u2010free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased natural killer cells"],"prefix":"10.1111","volume":"191","author":[{"given":"Yazad D.","family":"Irani","sequence":"first","affiliation":[{"name":"Precision Medicine Theme South Australia Health and Medical Research Institute (SAHMRI) Adelaide South 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