{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:15:29Z","timestamp":1791256529898,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T00:00:00Z","timestamp":1590278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Novartis Pharmaceuticals UK Ltd."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Management of chronic myeloid leukaemia (CML) has recently undergone dramatic changes, prompting the European LeukemiaNet (ELN) to issue recommendations in 2013; however, it remains unclear whether real\u2010world CML management is consistent with these goals. We report results of UK TARGET CML, a retrospective observational study of 257 patients with chronic\u2010phase CML who had been prescribed a first\u2010line TKI between 2013 and 2017, most of whom received first\u2010line imatinib (<jats:italic>n<\/jats:italic>\u00a0=\u00a0203). Although 44% of patients required \u22651 change of TKI, these real\u2010world data revealed that molecular assessments were frequently missed, 23% of patients with ELN\u2010defined treatment failure did not switch TKI, and kinase domain mutation analysis was performed in only 49% of patients who switched TKI for resistance. Major molecular response (MMR; <jats:italic>BCR\u2010ABL1<\/jats:italic><jats:sup>IS<\/jats:sup> \u22640\u00b71%) and deep molecular response (DMR; <jats:italic>BCR\u2010ABL1<\/jats:italic><jats:sup>IS<\/jats:sup> \u22640\u00b701%) were observed in 50% and 29%, respectively, of patients treated with first\u2010line imatinib, and 63% and 54%, respectively, receiving a second\u2010generation TKI first line. MMR and DMR were also observed in 77% and 44% of evaluable patients with \u226513\u00a0months follow\u2010up, receiving a second\u2010generation TKI second line. We found little evidence that cardiovascular risk factors were considered during TKI management. These findings highlight key areas for improvement in providing optimal care to patients with CML.<\/jats:p>","DOI":"10.1111\/bjh.16733","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:59:21Z","timestamp":1590368361000},"page":"62-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Real\u2010world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study"],"prefix":"10.1111","volume":"192","author":[{"given":"Dragana","family":"Milojkovic","sequence":"first","affiliation":[{"name":"Hammersmith Hospital Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-2555","authenticated-orcid":false,"given":"Nicholas C. 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