{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:22:55Z","timestamp":1789010575246,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the clinicopathological features and prognostic factors of patients with peripheral T\u2010cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune\u2010related disorders (autoimmune 16%, viral infections 17%, chemo\/radiotherapy\u2010treated carcinomas 19%). The median progression\u2010free survival (PFS) and overall survival (OS) were 7\u00b79 and 15\u00b78\u00a0months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Complete response (CR) to treatment was associated with better PFS (62\u00b76 vs. 4\u00a0months; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and longer OS (67\u00b70 vs. 7\u00b73\u00a0months; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) compared to no CR. CD30 was expressed across all subtypes; &gt;15% of cells were positive in anaplastic lymphoma kinase\u2010positive and \u2010negative anaplastic large\u2010cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re\u2010evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub\u2010classification, and response level to first\u2010line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors.<\/jats:p>","DOI":"10.1111\/bjh.16741","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T18:58:22Z","timestamp":1589914702000},"page":"82-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical and pathological characteristics of peripheral T\u2010cell lymphomas in a Spanish population: a retrospective study"],"prefix":"10.1111","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-1327","authenticated-orcid":false,"given":"Socorro Maria","family":"Rodriguez\u2010Pinilla","sequence":"first","affiliation":[{"name":"Pathology Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, CIBERONC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Domingo\u2010Domenech","sequence":"additional","affiliation":[{"name":"Hematology Department Institut Catal\u00e0 d'Oncologia L'Hospitalet de Llobregat (Barcelona) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fina","family":"Climent","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitari de Bellvitge. IDIBELL, L'Hospitalet de Llobregat (Barcelona) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Hematology Department and Pathology Department Hospital Universitario Reina Sof\u00eda Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Perez Seoane","sequence":"additional","affiliation":[{"name":"Hematology Department and Pathology Department Hospital Universitario Reina Sof\u00eda Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Lopez Jimenez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Garcia\u2010Cosio","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Hospital Universitario Ram\u00f3n y Cajal, Madrid, CIBERONC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Caballero","sequence":"additional","affiliation":[{"name":"Hematology Department Hospitalario Universitario de Salamanca (HUS\/IBSAL) and CIBERONC Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Javier","family":"Blanco Mu\u00f1ez","sequence":"additional","affiliation":[{"name":"Pathology Department Complejo Asistencial Universitario de Salamanca\u2010IBSAL Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Carpio","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Castellvi","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martinez Pozo","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERONC, Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Gonzalez Farre","sequence":"additional","affiliation":[{"name":"Hematopathology Unit Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) CIBERONC Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Benda\u00f1a","sequence":"additional","affiliation":[{"name":"Hematology Department Complexo Hospitalario Universitario de Santiago de Compostela La Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Aliste","sequence":"additional","affiliation":[{"name":"Hematology Department Complexo Hospitalario Universitario de Santiago de Compostela La Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Julia","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Gonzalez de Villambrosia","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Piris","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid CIBERONC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Gomez Codina","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Empar","family":"Mayordomo\u2010Aranda","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Puerta de Hierro, Madrid, CIBERONC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Bellas","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Puerta de Hierro, Madrid, CIBERONC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS)\/Universidad de Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jose","family":"Borrero","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS)\/Universidad de Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ruiz\u2010Zorrilla","sequence":"additional","affiliation":[{"name":"Medical Department Takeda Farmac\u00e9utica Espa\u00f1a S.A Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Grande","sequence":"additional","affiliation":[{"name":"Medical Department Takeda Farmac\u00e9utica Espa\u00f1a S.A Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Montoto","sequence":"additional","affiliation":[{"name":"Medical Department Takeda Farmac\u00e9utica Espa\u00f1a S.A Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Cordoba","sequence":"additional","affiliation":[{"name":"Hematology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, CIBERONC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"World Health Organization Classification of Tumours","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186577"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15258"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90180-K"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-461848"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24044"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008418727472"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq359"},{"key":"e_1_2_8_12_1","first-page":"2474","article-title":"Intergruppo Italiano Linfomi","volume":"103","author":"Gallamini A","year":"2004","journal-title":"Periph T Cell Lymphoma"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0524"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24592"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(96)00075-X"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.364"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057673"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134270"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0105-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2013.04.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-018-0429-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30416"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001245"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28676"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0117"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv201"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1331"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1309\/R2Q9CCUVTLRYCF3H"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-584953"},{"key":"e_1_2_8_32_1","first-page":"13","article-title":"New biomarkers in T\u2010cell lymphomas. Bailli\u00e8re's best practice & research","volume":"25","author":"Bisig B","year":"2012","journal-title":"Clin Haematol"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.16741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.16741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T16:13:23Z","timestamp":1693757603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.16741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/bjh.16741"],"URL":"https:\/\/doi.org\/10.1111\/bjh.16741","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"2020-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}