{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:25:39Z","timestamp":1773527139465,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["1R01NS094041"],"award-info":[{"award-number":["1R01NS094041"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Severe anaemia, defined as haemoglobin level\u00a0&lt;\u00a06\u00b70\u00a0g\/dl, is an independent risk factor for death in individuals with sickle cell disease living in resource\u2010limited settings. We conducted a cross\u2010sectional study of 941 children with sickle cell anaemia, who had been defined as phenotype HbSS or HbS\u03b2<jats:sup>0<\/jats:sup> thalassaemia, aged five to 12\u00a0years, and were screened for enrollment into a large primary stroke prevention trial in Nigeria (SPRING; NCT02560935). The main aim of the study was to determine the prevalence and risk factors for severe anaemia. We found severe anaemia to be present in 3\u00b79% (37 of 941) of the SPRING study participants. Severe anaemia was significantly associated with the lower educational level of the head of the household (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003), as a proxy for poverty, and a greater number of children per room in the household (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004). Body mass index was not associated with severe anaemia. The etiology of severe anaemia in children living with sickle cell anaemia in Nigeria is likely to be multifactorial with an interplay between an individual's disease severity and other socio\u2010economic factors related to poverty.<\/jats:p>","DOI":"10.1111\/bjh.16746","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T14:09:01Z","timestamp":1589638141000},"page":"939-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Low educational level of head of household, as a proxy for poverty, is associated with severe anaemia among children with sickle cell disease living in a low\u2010resource setting: evidence from the SPRING trial"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-4548","authenticated-orcid":false,"given":"Halima","family":"Bello\u2010Manga","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Transfusion Barau Dikko Teaching Hospital\/Kaduna State University Kaduna Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha A.","family":"Galadanci","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Aminu Kano Teaching Hospital\/Bayero University Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehu","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aminu Kano Teaching Hospital\/Bayero University Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehi","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Radiology Aminu Kano Teaching Hospital\/Bayero University Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binta","family":"Jibir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hasiya Bayero Children's Hospital Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safiya","family":"Gambo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Murtala Muhammad Specialist Hospital Kano Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawal","family":"Haliru","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Barau Dikko Teaching Hospital\/Kaduna State University Kaduna Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori C.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Neurology Vanderbilt University of Medicine Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muktar H.","family":"Aliyu","sequence":"additional","affiliation":[{"name":"Family Medicine\/Preventive Medicine Vanderbilt Institute for Global Health Vanderbilt University Medical Center Nashville TN 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