{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:13:27Z","timestamp":1793812407935,"version":"4.6.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Relapses involving the central nervous system (CNS) are rare in children and adolescents with ALK+ anaplastic large cell lymphoma (ALCL) treated with regimens including CNS prophylaxis. Early identification of patients at high\u2010risk for CNS relapse would enable stratification and better adaptation of initial treatment especially in the light of the upcoming targeted therapies with limited CNS penetration. We analyzed clinical and histological data of all ALK+ALCL patients with CNS relapse registered in ALCL99\u2010database with the aim to describe risk factors and outcome. Characteristics of patients with no relapse, relapse without CNS involvement and CNS relapse were compared. At a median follow\u2010up of 8\u00a0years (0.05\u201318\u00a0years), a CNS involvement was reported at first or subsequent relapse in 26\/618 patients. Median interval between initial diagnosis and first CNS relapse was 8\u00a0months (IQR 5.55\u201310.61\/range 1.31\u2013130.69). The 5\u2010year cumulative risk of CNS relapse was 4% (95% CI 2.9\u20135.5). Bone marrow involvement, peripheral blasts and CNS involvement at diagnosis were more frequent in patients with CNS relapse than in patients with no relapse or with relapse with no CNS involvement. The treatment of CNS relapse was heterogeneous. The median survival after CNS relapse was 23.7\u00a0months. Eleven patients were alive at last follow\u2010up. Three\u2010year overall survival after CNS relapse was 48.70% (95% CI 30.52\u201367.23).<\/jats:p>","DOI":"10.1111\/bjh.16755","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T05:24:10Z","timestamp":1594358650000},"page":"1039-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neuro\u2010meningeal relapse in anaplastic large\u2010cell lymphoma: incidence, risk factors and prognosis \u2013 a report from the European intergroup for childhood non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3540-4331","authenticated-orcid":false,"given":"Giada","family":"Del Baldo","sequence":"first","affiliation":[{"name":"Department of Children and Adolescents Oncology Gustave Roussy Cancer Center Paris\u2010Saclay University Villejuif France"},{"name":"Department of Hematology\/Oncology, Cell and Gene Therapy Bambino Ges\u00f9 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