{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:34:25Z","timestamp":1789014865780,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["MRSG-14-052-01-LIB"],"award-info":[{"award-number":["MRSG-14-052-01-LIB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with relapsed\/refractory (R\/R) non\u2010Hodgkin lymphoma (NHL) have limited options for salvage, and checkpoint blockade therapy (CBT) has little efficacy. Usage in solid malignancies suggests that CBT sensitises tumours to subsequent chemotherapy. We performed the first analysis of CBT on subsequent NHL treatment. Seventeen North American centres retrospectively queried records. The primary aim was to evaluate the overall response rate (ORR) to post\u2010CBT treatment. Secondary aims included progression\u2010free survival (PFS), duration of response (DOR) and overall survival (OS). Fifty\u2010nine patients (68% aggressive NHL, 69% advanced disease) were included. Patients received a median of three therapies before CBT. Fifty\u2010three (90%) discontinued CBT due to progression. Post\u2010CBT regimens included chemotherapy (49%), targeted therapy (30%), clinical trial (17%), transplant conditioning (2%) and chimeric antigen receptor T cell (CAR\u2010T) therapy (2%). The ORR to post\u2010CBT treatment was 51%, with median PFS of 6\u00b71\u00a0months. In patients with at least stable disease (SD) to post\u2010CBT, the median DOR was significantly longer than to pre\u2010CBT (310 vs. 79\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) suggesting sensitisation. Nineteen patients were transplanted after post\u2010CBT therapy. Median overall survival was not reached, nor affected by regimen. Prospective trials are warranted, as this may offer R\/R NHL patients a novel therapeutic approach.<\/jats:p>","DOI":"10.1111\/bjh.16756","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T06:16:09Z","timestamp":1589955369000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Checkpoint blockade treatment sensitises relapsed\/refractory non\u2010Hodgkin lymphoma to subsequent therapy"],"prefix":"10.1111","volume":"191","author":[{"given":"Nicole A.","family":"Carreau","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology Perlmutter Cancer Center at NYU Langone Health New York University School of Medicine &amp; Langone Medical Center New York NY 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