{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:54:04Z","timestamp":1776372844261,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite continuing improvements in the management of classical Hodgkin lymphoma (cHL), relapse remains associated with a risk of lymphoma\u2010related mortality. The biological composition of relapse tumour biopsies shows interpatient variability, which can be leveraged to design prognostic biomarkers. Here, we validated the RHL30 assay, a previously reported gene expression model in an independent cohort of 41 patients with relapsed cHL. Patients classified as high\u2010risk by the RHL30 assay had inferior failure\u2010free survival (FFS) after autologous stem cell transplantation (2\u2010year FFS 41% vs. 92%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7035). The RHL30 model is a robust biomarker that risk\u2010stratifies patients considered for autologous stem cell transplantation.<\/jats:p>","DOI":"10.1111\/bjh.16777","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T14:03:58Z","timestamp":1591625038000},"page":"864-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Validation of the RHL30 digital gene expression assay as a prognostic biomarker for relapsed Hodgkin lymphoma"],"prefix":"10.1111","volume":"190","author":[{"given":"Lourdes","family":"Calvente","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Centre University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Tremblay\u2010LeMay","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program University Health Network Toronto ON 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