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We evaluated the potential role of terminal complement pathway in four patients with carfilzomib\u2010induced TMA. Membrane attack complex (C5b\u20109) deposition on endothelial cells in culture exposed to plasma from patients during the acute phase of the disease suggests complement overactivation as a mechanism of potential endothelial damage in three out of four patients. If confirmed in larger cohorts, C5b\u20109 evaluation will allow early identification of patients who could benefit from complement blockade and treatment monitoring.<\/jats:p>","DOI":"10.1111\/bjh.16796","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T09:07:30Z","timestamp":1590743250000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Complement as the enabler of carfilzomib\u2010induced thrombotic microangiopathy"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-7992","authenticated-orcid":false,"given":"Miquel","family":"Blasco","sequence":"first","affiliation":[{"name":"Nephrology and Kidney Transplantation Department Centro de Referencia en Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR) Hospital Cl\u00ednic University of Barcelona Barcelona Spain"},{"name":"Institute of Biomedical Research 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Cl\u00ednic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-9239","authenticated-orcid":false,"given":"Laura","family":"Rosi\u00f1ol","sequence":"additional","affiliation":[{"name":"Amyloidosis and Myeloma Unit Department of Hematology Hospital Cl\u00ednic of Barcelona Institute of Biomedical Research August Pi i Sunyer (IDIPABS) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit Hospital Cl\u00ednic Institute of Biomedical Research August Pi i Sunyer (IDIPABS) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit Hospital Cl\u00ednic Institute of Biomedical Research August Pi i Sunyer 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