{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:24Z","timestamp":1792174764105,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Francesco Olgiati Onlus"},{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondazione Policlinico Gemelli IRCCS"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Repeated red blood cell (RBC) transfusions in preterm neonates are associated with poor outcome and increased risk for prematurity\u2010associated diseases. RBC transfusions cause the progressive replacement of fetal haemoglobin (HbF) by adult haemoglobin (HbA). We monitored HbF levels in 25 preterm neonates until 36\u00a0weeks of post\u2010menstrual age (PMA); patients received RBC units from allogeneic cord blood (cord\u2010RBCs) or from adult donors (adult\u2010RBCs), depending on whether cord\u2010RBCs were available. Primary outcome was HbF level at PMA of 32\u00a0weeks. Twenty\u2010three neonates survived until this age: 14 received no transfusions, two only cord\u2010RBCs, three only adult\u2010RBCs and four both RBC types. HbF levels in neonates transfused with cord\u2010RBCs were significantly higher than in neonates receiving adult\u2010RBCs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) or both RBC types (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). Superimposable results were obtained at PMA of 36\u00a0weeks. Every adult\u2010RBCs transfusion increased the risk for an HbF in the lowest quartile by about 10\u2010fold, whereas this effect was not evident if combined adult\u2010 and cord\u2010RBCs were evaluated. Overall, these data show that transfusing cord\u2010RBCs can limit the HbF depletion caused by conventional RBC transfusions. Transfusing cord blood warrants investigation in randomised trials as a strategy to mitigate the severity of retinopathy of prematurity (NCT03764813).<\/jats:p>","DOI":"10.1111\/bjh.16851","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T15:07:17Z","timestamp":1591628837000},"page":"263-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Allogeneic cord blood transfusions prevent fetal haemoglobin depletion in preterm neonates. Results of the CB\u2010TrIP study"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-1561","authenticated-orcid":false,"given":"Luciana","family":"Teofili","sequence":"first","affiliation":[{"name":"Dipartimento di Diagnostica per Immagini Radioterapia Oncologica, ed Ematologia Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy"},{"name":"Universit\u00e0 Cattolica del Sacro, Cuore Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Papacci","sequence":"additional","affiliation":[{"name":"Area Salute del Bambino Fondazione Policlinico Universitario A. 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