{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:15:21Z","timestamp":1787505321996,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kinderkrebshilfe S\u00fcdtirol-Regenbogen"},{"name":"Kinderkrebshilfe Tirol und Vorarlberg"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Fluconazole is one of the most commonly used drugs for antifungal prophylaxis in childhood leukaemia. However, its interaction with vincristine may induce neuropathy and the emergence of antifungal drug resistance contributes to substantial mortality caused by invasive fungal infections (IFIs). In a retrospective single\u2010centre study, we compared tolerability and outcome of different antifungal prophylaxis strategies in 198 children with acute leukaemia (median age 5\u00b73\u00a0years). Until 2010, antifungal prophylaxis with fluconazole was offered to most of the patients and thereafter was replaced by liposomal amphotericin\u2010B (L\u2010AMB) and restricted to high\u2010risk patients only. Vincristine\u2010induced neurotoxicity was significantly reduced under L\u2010AMB, as the percentage of patients with severe constipation decreased (15\u00b74% vs. 3\u00b77%, before vs. after 31 December\u00b72010,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b701) and stool frequency increased by up to 38% in polyene\u2010treated patients (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7005). Before 2011, 10 patients developed confirmed IFIs, most of them were infected with\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species. After risk adaption in 2011, IFIs were completely prevented (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7007).\n                  <\/jats:p>\n                  <jats:p>L\u2010AMB prophylaxis is beneficial in childhood leukaemia patients, as it offers effective antifungal activity with improved tolerability as compared to fluconazole. The potential impact of our risk\u2010adapted antifungal treatment should be included in current prophylaxis guidelines for childhood leukaemia.<\/jats:p>","DOI":"10.1111\/bjh.16931","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T05:24:22Z","timestamp":1593840262000},"page":"816-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Benefits of risk\u2010adapted and mould\u2010specific antifungal prophylaxis in childhood leukaemia"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-5334","authenticated-orcid":false,"given":"Andreas","family":"Meryk","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Kropshofer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics 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