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Platelet responses \u226550\u00a0000\/\u00b5l were observed in 25\/32 (78%) second\u2010line and 54\/113 (48%) third\u2010or\u2010later\u2010line patients. Bleeding events were less frequent in second\u2010line (28%) versus third\u2010or\u2010later\u2010line (45%) patients. Responses once achieved tended to be durable in both groups. The safety profile was similar in both groups. In this\n                    <jats:italic>post hoc<\/jats:italic>\n                    analysis, fostamatinib was more effective as second\u2010line than third\u2010or\u2010later\u2010line therapy for ITP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.16959","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T22:54:55Z","timestamp":1595544895000},"page":"933-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Fostamatinib is an effective second\u2010line therapy in patients with immune thrombocytopenia"],"prefix":"10.1111","volume":"190","author":[{"given":"Ralph","family":"Boccia","sequence":"first","affiliation":[{"name":"Centre for Cancer and Blood Disorders Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichola","family":"Cooper","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust Hammersmith Hospital 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